男性免疫性避孕疫苗的应用研究  

Application Study on Male Immunocontraceptive Vaccine

作　　者：朱秀兰[1] 马文丽[1] 德伟[2] 郑文岭[1] 

机构地区：[1]南方医科大学基因工程研究所,广州市510515 [2]南京医科大学生物化学与分子生物学系,南京市210029

出　　处：《医学分子生物学杂志》2008年第5期454-457,共4页Journal of Medical Molecular Biology

基　　金：广东省重点实验室建设基金(No.2004B60144)~~

摘　　要：近年来男性免疫性避孕控制生育的研究日益增多。男性免疫避孕的理想目标是在不影响性激素水平、性欲和性功能的基础上研制出一种高效、安全、可逆的避孕疫苗,其基本原理是通过外源性靶抗原抗体中和体内生殖激素的作用,抑制精子发生,进而避孕。研究方法主要从生殖激素(GnRH、FSH、LH及其相应受体)和精子中筛选最为合适的靶抗原用于免疫避孕疫苗的研究,睾酮激素下降明显、抗体滴度小、精子不可逆抑制是目前存在的常见问题。当今选择特异结合靶点抗原以及精子相关靶抗原进行免疫性避孕的方法有效促进了男性避孕疫苗的开发,是有前景的研究重点之一。An ideal aim for male immunoeontraception is to develop one kind of contraceptive vaccine with high performance, safety and reversibility but not affecting gonadal hormone level, libido and sexual function. The principle is based on immunoneutralization of reproductive hormone function and suppression of spermatogenesis. Many methods being studied mainly focus on screening the most suitable target antigen from reproductive hormones and sperm correlated antigens. Extreme decease of testosterone, low antibody titer and the irreversible suppression of spermatogenesis are the common problems. Currently, specific binding to targeting antigens and sperm related antigens has been used to effectively enhance the development of male contraceptive vaccine and is one of the prospective points.

关 键 词：免疫避孕 疫苗 男性避孕 激素 

分 类 号：R979.21[医药卫生—药品] R169.41[医药卫生—药学]