动物抗菌肽的抗病毒活性  

Antiviral Function of Animal Antimicrobial Peptides

作　　者：赵洁[1] 孙燕[1] 李晶[2] 李治[1] 

机构地区：[1]陕西师范大学生命科学学院,西安市710062 [2]襄樊市中心医院感染性疾病科,湖北省襄樊市441021

出　　处：《医学分子生物学杂志》2008年第5期466-469,共4页Journal of Medical Molecular Biology

基　　金：陕西师范大学实验室开放基金;大学生创新性实验计划项目资助

摘　　要：抗菌肽不仅具有抗细菌作用,某些抗菌肽还具有抗真菌甚至抑制病毒的活性。哺乳动物的防御素家族和两栖动物的Magainin家族、Brevinin-1家族、Maximins家族抗菌肽的成员,以及某些蜘蛛抗菌肽、虾抗菌肽、鲎抗菌肽等均具有抵御包膜病毒(如单纯疱疹病毒、人免疫缺陷病毒、流感病毒)的活性。抗菌肽的抗包膜病毒机制是其与病毒包膜相互作用而破坏病毒完整性,此外,抗菌肽亦可能参与机体免疫途径而抑制病毒。防御素等也具有抑制无包膜病毒(如人乳头瘤病毒、呼吸道轮状病毒、腺病毒)的活性,其可能途径是通过阻断病毒粒子释放达到抑制病毒传播的作用。Antimicrobial Peptides （AMPs） inhibits not only bacterial, but also fungal and viral infections. Defensins family derived from mammalian, Magainin, Brevinin-1, Maximins families from amphibian, and some antimicrobial peptides from spider, shrimp and limuloid, possess the activity to inhibit the viruses with envelope, such as HSV, HIV and IAV. The antiviral mechanism results from AMPs that interact with viral envelope, thus destroying envelope integrality of virus. In addition, AMPs activates immune pathways to inhibit viruses. Defensins and some other AMPs also inhibit viruses without envelope, such as HPV, RV-SA11 and AD. In this case, the antiviral approach is possibly achieved via AMPs which block the release of viral particles, thereby preventing virus diffusion.

关 键 词：抗菌肽 抗病毒活性 

分 类 号：Q939.93[生物学—微生物学] R978.7[医药卫生—药品]