腹内高压对猪呼吸功能影响的实验研究  

Influence of intra-abdominal hypertension on respiratory function in pigs

作　　者：胡建华[1] 王大庆[2] 涂发平[1] 陈斌[1] 葛颖[2] 刘少星[2] 龚宗炼[2] 万勇[2] 

机构地区：[1]川北医学院附属医院麻醉科,四川南充637000 [2]川北医学院附属医院ICU,四川南充637000

出　　处：《中国呼吸与危重监护杂志》2008年第5期383-384,382,共3页Chinese Journal of Respiratory and Critical Care Medicine

基　　金：四川省科技厅重点攻关项目(编号:04SG022-027)

摘　　要：目的研究腹内高压(IAH)对猪呼吸功能的影响。方法将12只家猪随机分为IAH20组(腹内压20 mm Hg)和IAH30组(腹内压30 mm Hg),应用二氧化碳气腹法制备腹内高压动物模型,建立模型后分别于不同时点测定动态顺应性(Cdyn)、吸气峰压(PIP)、SpO2、PaCO2等呼吸参数。结果IAH30组内各时点的Cdyn较基础值低(P均<0.05),与IAH20组相应时点比较Cdyn明显下降(P均<0.05);两组间各时点PIP均较基础值明显升高(P均<0.05),IAH30组相应时点的PIP亦较IAH20组明显增高(P均<0.05)。而SpO2、PaCO2在组内及组间均无明显变化。结论腹内高压导致Cdyn下降,PIP增加,对呼吸功能有一定损害。Objective To investigate the effect of intra-abdominal hypertension （IAH） on respiratory function in pigs. Methods Twelve pigs were randomly divided into two groups （n = 6 in each group）, ie. IAH30 group （intra-abdominal pressure =20 mm Hg） and IAH30 group （intra-abdominal pressure = 30 mm Hg）. Pig model of IAH was established by iutraperitoneally injection of carbon dioxide. The changes in respiratory function parameters including pulmonary dynamic compliance （Cdyn）, peak inspiratory pressure （PIP） , SpO2 and PaCO2 were recorded at different time points. Results Cdyn was significantly decreased at different time points compared with baseline in group IAH30 and group IAH20. PIP significantly increased at different time points compared with baseline in both IAH groups,but group IAH30 was more severe than group IAH20. No significant changes of SpO2 and PaCO2 were found in two IAH groups. Conclusion IAH can impair respiratory function by decreasing lung compliance and increasing inspiratory pressure.

关 键 词：腹内高压 呼吸功能 猪 临床研究 

分 类 号：R656[医药卫生—外科学] R614.42[医药卫生—临床医学]