伊洛前列素治疗儿童先天性心脏病并肺动脉高压临床研究  

Clinic research of Hoprost in patients with congenital heart disease associated with pulmonary hypertension

作　　者：王志伟[1] 姚霖 杨晓涵[1] 郭建州[1] 于洪涛[1] 秦继红[1] 

机构地区：[1]深圳市孙逸仙心血管医院心外科,广东省深圳518020 [2]广东省深圳市福田人民医院儿科

出　　处：《中国基层医药》2008年第9期1415-1416,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省深圳市卫生局重点科技项目（编号：06042）

摘　　要：目的探讨吸入伊洛前列素（万他维）对先天性心脏病（先心病）并肺动脉高压患儿心功能的影响。方法选择一组先心病患儿术前用口含器或面罩吸入万他维，剂量为25—30ng·kg^-1·min^-1，以2m10．9％氯化钠溶液稀释后，通过PARI Junior BOY N压缩机压缩雾化吸人，每3小时给药一次，吸入60min、120min、180min后采用连续多普勒超声波技术，测量左右心每搏心排量等血流动力学参数变化。结果在用药前和后60min、120min、180min，除血流动力学有明显变化，还发现用药后左、右心排血量增加，用药后再行手术的患儿，呼吸机带管时间缩短，术后恢复顺利。结论吸入伊洛前列素可以增加心输出量，改善心功能，提示该方法治疗先心病并肺动脉高压有效可行。Objective To explore the effect of inhaled iloprost （Ventavis） for patients with congenital heart disease associated with pulmonary hypertension. Methods Twenty-two patients with congenital heart disease associ- ated with pulmonary hypertension were selected to inhale Ventavis by atomizer before surgery , the required dosage is 25-30ng/（ kg. min ） , aerosolization of iloprost was inhaled by PAR] Junior BOY N after diluted with 2ml physiologi- cal saline at 3-hour intervals . The change of hemodynamie effects was measured by Doppler ultrasonography after 60min,120min,and 180min. Results The left and right ventricular cardiac output at 60min,120min and 180min after therapy were markedly higher than that before inhaled iloprost , respirator therapy time was shorter in patients inhaled iloprost. Conclusion inhaled iloprost can increase cardiac output and improve patients＇ cardiac funetion. Thus, the therapy with inhaled iloprost is effective and feasible.

关 键 词：伊洛前列素 心脏缺损 先天性 高血压 肺性 儿童 

分 类 号：R72[医药卫生—儿科] R726[医药卫生—临床医学]