前S1抗原检测在乙型肝炎诊断中的应用  

Application of Pre-S1 antigen in the diagnosis of hepatitis B

作　　者：孙振平 

机构地区：[1]天津开发区医院检验科,天津市300457

出　　处：《中国基层医药》2008年第9期1468-1469,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的通过对乙型肝炎病毒（HBV）前S1抗原与HBV血清标志物检测的对比分析，对HBV前S1抗原的临床意义进行探讨。方法用酶联免疫吸附实验（ELISA）对HBV血清标志物和HBV前s1抗原进行检测。结果对HBV血清标志物不同组合模式进行分析发现：HBV血清标志物传染性强（HBeAg阳性）的模式中，HBV前s1抗原的检出率为94．0％；HBV血清标志物传染性弱（HBeAg阴性）的模式中，HBV前s1抗原的检出率为15．6％；乙肝表面抗原（HBsAg）、乙肝e抗原（HBeAg）均为阴性的模式中，HBV前S1抗原均是阴性。结论HBV前S1抗原与HBeAg在很大程度上具有一致性，其阳性可作为HBV复制的重要依据和HBV存在的指标。Objective To analyze and compare the Pre-S1 antigen and the serum markers to discuss the clinical significance of the Pre-S1 antigen of HBV. Methods The serum markers and the Pre-S1 antigen of HBV were detected by ELISA. Result By analyzing the serum markers in different combination modes, we found that the detection rate of the Pre-S1 antigen in different combination modes are ：94% （in the HBeAg positive mode） ;15. 6% （ in the HBeAg negative mode） and negative in the mode both HBsAg and HBeAg are negative. Conclusions The Pre-S1 antigen of HBV has a coherence with HBeAg to a large extent, and has contact relations with the exist and rep- licate of HBV and can reflect the replication of HBV. The detection of the Pre-S1 antigen can help the diagnosis of HBV infection.

关 键 词：肝炎病毒 乙型 前S1抗原 病毒复制 

分 类 号：R446[医药卫生—诊断学] R51[医药卫生—临床医学]