地塞米松眼部植入剂的制备  

Preparation of Dexamethasone Ocular Implant

作　　者：杨莉[1] 张惠平[1] 栾瀚森[1] 陈凯栋 侯惠民[1] 

机构地区：[1]药物制剂国家工程研究中心,上海201203 [2]北京紫竹药业有限公司,北京100024

出　　处：《中国医药工业杂志》2008年第10期741-744,共4页Chinese Journal of Pharmaceuticals

摘　　要：以生物可降解的乙交酯-丙交酯共聚物(PLGA)为载体,用溶剂法制备了地塞米松眼部植入剂。考察了处方中PLGA的构成和重均分子量、药物含量及释放调节剂对植入剂体外释放的影响。结果表明用分子量较小、乙交酯和丙交酯的摩尔比为50:50的PLGA制备的植入剂体外释药较快;提高药物含量、选用亲水性调节剂或乳酸也能加快体外释放。The ocular implant loaded with dexamethasone was prepared by solvent method with the biodegradable polymer, polylactic-co-glycolic acid （PLGA） as carriers. The in vitro release was affected by the weightaverage molecular weight and monomer ratio LA/GA of PLGA, the drug loading and other excipients in the formulation. The results demonstrated that the in vitro release velocity was faster when the implant was prepared by PLGA with the lower weight-average molecular weight and LA/GA of 50 ： 50, addition of hydrophilic excipients or lactic acid.

关 键 词：眼部植入剂 乙交酯-丙交酯共聚物 地塞米松 体外释药 制备 

分 类 号：R944.9[医药卫生—药剂学]