微波辐射下纳米CeO2催化合成氯乙酸乙酯  

Catalytic Synthesis of Ethyl Chloroacetate by Nanometer CeO_2 under Microwave Irradiation

作　　者：邓斌[1] 章爱华[2] 徐安武[3] 

机构地区：[1]湘南学院化学与生命科学系,湖南郴州423000 [2]吉首大学化学化工学院,湖南吉首416000 [3]中国科技大学合肥微尺度物质科学国家实验室,安徽合肥230026

出　　处：《合成化学》2008年第5期586-588,共3页Chinese Journal of Synthetic Chemistry

基　　金：湖南省教育厅优秀青年科研基金资助项目(06B089)

摘　　要：微波辐射下,纳米CeO2催化氯乙酸和无水乙醇反应合成了氯乙酸乙酯。经正交试验优选出的最佳反应条件为:氯乙酸200mmol,n(无水乙醇)∶n(氯乙酸)=2∶1,w(CeO2)=1.0%,500W微波辐射下反应8min,酯化率98%。Ethyl chloroacetate was synthesized by esterification of chloroacetic acid and ethanol using nanometer CeO2 as a catalyst under microwave irradiation. The optimum reaction conditions from orthogonal experiments were as follows： chloroacetic acid was 200 mmol; n （ethanol） ： n （chloroacetic acid） was 2 ： 1 ; w（CeO2） was 1% ; microwave irradiation time was 8 min at 500 W power. The esterification yield was more than 98% under the conditions.

关 键 词：氯乙酸乙酯 CEO2 微波辐射 合成 

分 类 号：O623.64[理学—有机化学]