栀子苷大鼠在体肠吸收动力学的研究  

Study on absorption kinetics of geniposide in rat intestines

作　　者：杜先华[1] 牛欣[1] 冯前进[2] 杜红[1] 李海燕[1] 

机构地区：[1]北京中医药大学,北京100029 [2]山西中医学院,山西太原030024

出　　处：《华西药学杂志》2008年第5期558-560,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家"十五"攻关课题(2004BA721A46)

摘　　要：目的研究栀子苷大鼠在体肠吸收动力学的特征。方法采用大鼠在体肠吸收模型，UV法和HPLC法分别测定酚红和栀子苷的含量。考察药物质量浓度、不同肠段对栀子苷吸收的影响。结果栀子苷20～120μg·ml-1对小肠吸收速率常数如无影响；十二指肠、空肠、回肠、结肠的腼值分别为0．0240、0．0251、0．0234、0．0239h-1，各肠段的吸收速率常数勋无显著性差异。结论栀子苷在大鼠肠道的吸收呈一级动力学过程，为被动扩散。栀子苷具广泛的吸收窗，可制成缓释制剂。OBJECTIVE To investigate the absorption kinetics of geniposide in rat intestines. METHODS The concentrations of phenol red and geniposide by in situ perfusion in rats were determined by UV and HPLC, respectively. The effects of drug concentra- tions and various intestinal segments on the absorption had been studied. RESULTS The concentrations of 20 - 120μg·ml-1 had no obvious effects on absorption rate constants （Ka） of geniposide. The Ka values in duodenum,jejunum,ileum and colon were 0. 0240, 0. 0251,0. 0234,0. 0239 h-1, respectively. The absorption of geniposide at various segments had no significant difference, CONCLU- SION The absorption of geniposide was a first order process with passive diffusion mechanism. The extensive absorption segments of geniposide suggested that it can be processed into a sustained - release preparation.

关 键 词：栀子苷 肠吸收动力学 紫外光谱法 高效液相色谱法 

分 类 号：R96[医药卫生—药理学]