硫普罗宁对大鼠创伤性脑损伤后应激性肝损害的保护作用  

Tiopronin protects rats against hepatic stress injury induced by traumatic brain injury

作　　者：孟庆颖[1] 朱玉群[1] 

机构地区：[1]首都医科大学附属北京天坛医院消化内科,北京100050

出　　处：《中国新药杂志》2008年第18期1592-1594,共3页Chinese Journal of New Drugs

摘　　要：目的:探讨硫普罗宁在大鼠创伤性脑损伤后应激性肝损害的保护作用。方法:采用Feeney s自由落体撞击法建立创伤性脑损伤后应激性肝损害模型。于致伤后不同时间点(1,3,6,12和24 h)腹腔注射硫普罗宁300 mg.kg-1,测定大鼠肝组织超氧化物歧化酶(SOD)、丙二醛(MDA),血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST),并观察肝脏组织病理改变。结果:硫普罗宁各时间点给药组的大鼠肝细胞病理学改变显著减轻,肝组织SOD,MDA和血清ALT,AST有所改善,早期给药,作用越显著。结论:硫普罗宁作为抗氧化剂可用于防治创伤性脑损伤引起的应激性肝损害,尤其是在颅脑损伤早期应用效果更好。Objective： To explore the protection by tiopronin against hepatic stress injury （HSI） induced by traumatic brain injury （TBI） in rats. Methods： HSI was induced by TBI （Feeney＇s weight-dropping method）. Tiopronin （300 mg.kg^-1 ） was injected intraperitoneally for 2 days starting from various time points （ 1, 3, 6, 12 and 24 h） after TBI. The serum levels of ALT and AST, and the levels of MDA and SOD in the hepatic tissue were measured; the histological alterations were observed. Results： Tiopronin treatment at each time point significantly attenuated the histological injury. It also alleviated the changes in serum levels of ALT and AST, and the levels of MDA and SOD in the hepatic tissue as compared with the control. The effect was better when tiopronin was injected earlier. Conclusion： Tiopronin possesses a protective effect on TBI-induced HSI, which may be probably due to its antioxidant activity especially when administered in early stage.

关 键 词：硫普罗宁 应激性肝损害 创伤性脑损伤 氧自由基 抗氧化剂 

分 类 号：R965.1[医药卫生—药理学] R975.5[医药卫生—药学]