Synthesis and Crystal Structure Analysis of 5′-O-Tosyl-2,3′-anhydrothymidine  

作　　者：赵兴俄 尚培华 成昌梅 王如骥 赵玉芬 

机构地区：[1]College of Chemistry,Xiangtan University [2]Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology,Ministry of Education,Department of Chemistry,School of Life Sciences and Engineering,Tsinghua University

出　　处：《Chinese Journal of Structural Chemistry》2008年第10期1175-1180,共6页结构化学（英文）

基　　金：the National Natural Science Foundation of China(No.20132020)

摘　　要：In this paper, 5＇-O-tosyl-2,3＇-anhydrothymidine has been synthesized and its crystal structure was analyzed. The crystal belongs to the triclinic system, space group P1, with a = 5.397（2）, b = 6.1886（18）, c = 3.507（5）A, α = 87.74（2）,β = 89.84（4）,γ = 73.79（2）°, C17H18N2O6S, Mr = 378,39, Z = 1, V = 432.8（3）A^3, Dc = 1.452 g/cm^3, F（000） = 198 and Flack = -0.11（14）. No intermolecular hydrogen bonds exist in the crystal, and the angle between benzene ring and pyrimidine planes is 32.23°.In this paper, 5＇-O-tosyl-2,3＇-anhydrothymidine has been synthesized and its crystal structure was analyzed. The crystal belongs to the triclinic system, space group P1, with a = 5.397（2）, b = 6.1886（18）, c = 3.507（5）A, α = 87.74（2）,β = 89.84（4）,γ = 73.79（2）°, C17H18N2O6S, Mr = 378,39, Z = 1, V = 432.8（3）A^3, Dc = 1.452 g/cm^3, F（000） = 198 and Flack = -0.11（14）. No intermolecular hydrogen bonds exist in the crystal, and the angle between benzene ring and pyrimidine planes is 32.23°.

关 键 词：5＇-O-tosyl-2 3＇-anhydrothymidine SYNTHESIS X-ray diffraction crystal structure 

分 类 号：O626.41[理学—有机化学]