杂Diels-Alder反应在合成哌啶衍生物中的应用  

Application of hetero-Diels-Alder reaction in synthesis of piperidine derivatives

作　　者：王春燕[1] 夏之宁[1] 穆小静[1] 蔡高[1] 

机构地区：[1]重庆大学化学化工学院,重庆400030

出　　处：《化学试剂》2008年第10期743-747,共5页Chemical Reagents

基　　金：科技部国际合作项目(2006DFA43520);国家自然科学基金资助项目(20775096);重庆市自然科学基金项目(CQCSTC2006BB5011)

摘　　要：Diels-Alder反应是构建六元环的重要方法之一,按照反应过程中分子内和分子间成键的不同分类,分别介绍了近年来以Danishefsky二烯和亚胺为原料(正常电子需求),或者以氮杂二烯与烯烃为原料(反电子需求)的杂Diels-Alder反应在构建哌啶衍生物方面的应用,并进一步介绍了以手性原料或手性催化剂进行的杂Diels-Alder反应在不对称合成光学纯哌啶衍生物中的应用。Diels-Alder methodology is one of the most important ways to form six-member rings.Hetero-Diels-Alder reaction attracts attention in the synthesis of piperidine derivatives.According to intramolecular/intermolecular bonding,the advances in the synthesis of piperidine derivatives using Hetero-Diels-Alder reaction were reviewed.The Diels-Alder reactions using Danishefsky diene and imine as raw materials（normal electronic demand）,and using the aza-diene and olefins as raw materials（inverse electronic demand） were presented,respectively.Furthermore,the asymmetric synthesis of piperidine derivatives using chiral ingredients or chiral catalysts was also discussed.

关 键 词：哌啶衍生物 杂Diels-Alder反应 不对称合成 

分 类 号：O623[理学—有机化学]