钯催化二级芳胺的合成  

Palladium-catalyzed synthesis of secondary arylamines

作　　者：张文官[1] 何志群[2] 赵生敏[1] 王永生[2] 穆林平[2] 

机构地区：[1]北京印刷学院印刷包装材料与技术北京市重点实验室,北京102600 [2]北京交通大学光电子技术研究所,北京100044

出　　处：《化学试剂》2008年第10期781-783,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20674004;10434030);国家重点基础研究计划(2003CB314707);北京市教育委员会科技发展计划面上项目(KM200710015009);北京市优秀人才培养专项资助项目(20041D0500410)

摘　　要：以醋酸钯、膦配体二(2-二苯膦基)二苯醚(DPEphos)作为高活性催化系统,合成3个新的二级胺化合物N-苯基-3,5-二甲基苯胺、N-3,5-二甲苯对甲氧基苯胺和-N3,5-二甲苯基-2-吡啶胺。双齿螯合物膦配体bis[2-(diphenylphosphino]phenyl)ether(DPEphos),价格便宜可适于各种二级芳胺的较大规模制备。通过IR1、HNMR1、3CNMR、MS等确认其结构。实验初步证实溴代芳烃苯环上的给电子、吸电子基团对反应产率有显著的影响。In this paper,a highly active catalyst system for synthesizing three novel secondary amines,such as N-phenyl-3,5-dimethylaniline,N-3,5-dimethylphenyl-4-methoxyaniline,N-3,5-dimethylphenyl-2-pyridylamine,was formed by combination of the chelating ligand bis[2-（diphenylphosphino]phenyl）ether（DPEphos） with palladium acetate.DPEphos was used for the preparation of various secondary amines in large quantity and at low cost.The structures of diamines were confirmed by IR,1HNMR,13CNMR,and MS.The electron-poor or electron-rich groups of aryl bromides substrates had a remarkable effect on reaction yields,which were verified primarily.

关 键 词：醋酸钯 二(2-二苯膦基)二苯醚 二级芳胺 催化 

分 类 号：O625.63[理学—有机化学]