哺乳动物细胞衰老调节的新机制——端粒的表观遗传修饰  

Novel Mechanism of Mammalian Cellular Aging Regulation——Epigenetic Regulation of Telomeres

作　　者：郭艳合[1] 张义玲[1] 刘立[1] 王毅刚[1] 钱程[1] 

机构地区：[1]浙江理工大学生命科学学院,新元医学与生物技术研究所,杭州310018

出　　处：《中国生物化学与分子生物学报》2008年第10期895-901,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家重点基础研究发展规划基金项目(973计划;No.2004CB518804);国家高科技研究发展计划项目(863计划;No.2006AA02Z126);浙江省科技支撑与攻关计划面上项目(No.2007C33027)资助~~

摘　　要：端粒(telomere)是位于真核生物染色体末端的保护性结构,在调节细胞衰老及细胞寿命等方面具有重要意义.人们已在端粒结构中鉴定出了一系列的蛋白因子,如TRF1、TRF2、Pot1,Rap1、Tin2等,这些因子在保护端粒以及维持端粒合适长度的过程中具有重要作用.最近人们发现,在端粒结构以及亚端粒区域中存在丰富的表观遗传修饰,该类修饰包括组蛋白的三甲基化、组蛋白的乙酰基化以及DNA的甲基化等.并且发现这些修饰在端粒长度调节过程以及端粒相关疾病的发生发展过程中具有重要意义.人们推测,该机制可能对哺乳动物的衰老过程以及衰老相关的疾病等方面具有重要的调节作用.本文将对这些方面的最新研究进展作一介绍.Telomere lies at the end of eukaryotic chromosome, playing important roles in modulating cell senescence and cell life-span. Over the past few years, a series of proteins in the telomere were identified, such as TRF1, TRF2, Pot1, Rap1, Tin2, which play important roles in the process of telomere protection and maintain a suitable length of the telomere. Recently, it has been reported that there are abundant epigenetic modifications in telomere and subtelomere region, including histone trimethylation, histone acetylation and DNA methylation. These modifications are of great importance in regulating telomere length, and are relation with telomere-related diseases. It has been presumed that the mechanism has a significant role in the process of mammalian aging and the complicated diseases relating to aging in the mammals. This review will focus on the latest progress in these areas.

关 键 词：端粒 表观遗传修饰 甲基化 

分 类 号：Q255[生物学—细胞生物学] Q311