彩色多普勒超声重复照射对仔鼠学习记忆能力的影响  

Effect of Doppler Ultrasound during Different Durations of Pregnancy on Offspring’ Learning and Memorizing Abilities

作　　者：王勇[1] 段云友[1] 周宁[1] 熊华强[1] 曹铁生[1] 袁丽君[1] 

机构地区：[1]解放军第四军医大学唐都超声科

出　　处：《中国超声医学杂志》2008年第10期868-870,共3页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学资助(No.30571966)

摘　　要：目的探讨不同孕期彩色多普勒超声重复照射对仔鼠学习记忆能力的影响。方法妊娠SD大鼠30只,随机分为对照组、重复照射10min组、重复照射20min组3组。在妊娠第6、12、18d分别给予0、10、20min的(3.0MHz,MI=1.6,Tis=1.8)超声辐照。生后90d进行Morris水迷宫行为测试,评价其学习记忆能力。结果与对照组相比,辐射20min组仔鼠的上台潜伏期明显延长(P<0.05),目标象限游泳时间的百分比和穿台次数显著降低(P<0.05);而10min组则无明显差异(P>0.05)。结论孕期20min重复照射可能对仔鼠的学习记忆能力产生影响。Objective To investigate whether Doppler ultrasound with different doses during different durations of pregnancy could effect on offspring＇ learning and memorizing abilities. Methods Thirty pregnant SD rats were randomly divided into three groups according to the exposure time： control group （0 rain group）, 10 rain group and 20 min group. The rats were exposed to continuous ultrasound （3.0 MHz, MI=1.6, Tis=1.8） on 6th, 12th, and 18th days of gestation. In each group 90 days old neonatal rats were selected to do Morris water maze test for evaluating learning and memory abilities. Results The escape latencies of rats in 20 rain group were significantly longer than those of the control group （P〈0.05）, the time spent percent in the target quadrant and the numbers of crossing the plate in 20 min group were significantly lower than those of the control group; whereas there were no differences between the 10 min group and the control group （P：〉0.05）. Conclusions Doppler ultrasound over 20 min radiation during different durations of pregnancy may affect offspring＇ learning and memorizing abilities.

关 键 词：彩色多普勒超声 大鼠 MORRIS水迷宫 学习 记忆 

分 类 号：R445.1[医药卫生—影像医学与核医学] R715[医药卫生—诊断学]