超声背向散射积分技术评价诊断超声结合微泡造影剂助溶静脉血栓的实验研究  

Evaluation of Thrombolysis of Diagnostic Ultrasound with Microbubble Agent Using Integrated Backscatter

作　　者：陈冉[1] 任卫东[1] 马春燕[1] 陈昕[1] 程艳彬[1] 

机构地区：[1]中国医科大学第一附属医院心脏血管检查中心,沈阳市110001

出　　处：《中国超声医学杂志》2008年第10期878-880,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的应用超声背向散射积分技术(integrated backscatter,IBS)对兔股静脉溶栓后血栓状态进行检测,评价诊断超声结合微泡造影剂的助溶作用。方法健康家兔32只,建立兔右股静脉完全梗阻型血栓模型,将其分为单纯尿激酶组(UK组)8只,超声结合微泡造影剂组(US+MC组)8只,超声结合微泡造影剂+尿激酶组(US+MC+UK组)8只,对照组8只。使用HP5500型彩色超声诊断仪,检测溶栓后管腔内不同回声血栓块超声背向散射积分(IBS)值及管腔外膜IBS值,并计算管腔内血栓块IBS值与管腔外膜IBS值比值,即校正IBS值(IBS%)。并进行组间比较。取各组溶栓后的兔股静脉标本进行免疫组化检测,观察管腔内血栓溶解情况。结果溶栓后,US+MC+UK组管腔回声为无回声,其IBS%值0.29±0.05;UK组以弱回声为主的混合回声,IBS%值为0.58±0.03;US+MC组以中等回声为主的混合回声,IBS%值为0.89±0.06;对照组管腔呈强回声,其IBS%值1.23±0.17;US+MC+UK组IBS%值显著低于各组(P<0.05);UK组、US+MC组均低于对照组(P<0.05),两组间亦有统计学差异。结论IBS技术可以对溶栓后管腔内的不同回声进行定量分析,其结果表明诊断超声结合自制微泡造影剂对兔股静脉血栓有很好的助溶效应。Objective To identify the blood state of femoral vein in rat using Integrated Backscatter （IBS） and evaluate the effect of diagnostic ultrasound with microbubble agent on augmentation thrombolysis. Methods Thirtytwo rabbits of right femoral vein thrombosis were divided four groups： simple urokinase group, ultrasound and contrast microbubble group, ultrasound and contrast mierobubble and urokinase group, control group. With Color Doppler Ultrasonography, using IBS technique, the IBS values of the different type echo clot and vessel wall were measured. In addition, the ratios of IBS of different clot to IBS of vessel wall were calculated. These ratios were considered as the adjusted IBS （IBS%） of blood clot. Results IBS% of ultrasound and contrast microbubble and urokinase group were 0. 29±0. 05; IBS% of control group is 1.23±0.17; The anterior is significantly lower than other groups （P〈0. 05）. The simple urokinase group, ultrasound and contrast microbubble group were 0. 58±0. 03, 0.89±0. 06. The two group were lower than control group（P〈0. 05）. There is also difference between the two group （P〈0.05） . Conclusions Quantitative analysis of IBS in different echo of blood clot is feasible. It can be used to evaluate the effect of thrombolisis.

关 键 词：超声背向散射积分 诊断超声 微泡造影剂 

分 类 号：R445.1[医药卫生—影像医学与核医学] R454.3[医药卫生—诊断学]