I-TAC和MDC在病理性瘢痕中的表达及意义  

Expression of I-TAC and MDC and their significance in pathological scar

作　　者：王晨超[1] 郭澍[1] 唐明睿 肖汀[3] 于学伟[1] 张欣[1] 吴剑[3] 王凯波[3] 

机构地区：[1]中国医科大学附属第一医院整形外科,辽宁沈阳110001 [2]不详 [3]中国医科大学附属第一医院皮肤科,辽宁沈阳110001

出　　处：《中国美容整形外科杂志》2008年第5期344-347,共4页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的研究γ干扰素诱导的T细胞α亚族化学趋化因子(I-TAC)和巨噬细胞起源的趋化因子(MDC)在病理性瘢痕中的表达,探讨其在病理性瘢痕发病机制中的作用。方法应用免疫组化技术检测I-TAC和MDC两种趋化因子在24例瘢痕疙瘩患者(A组)、33例增生性瘢痕患者(B组)及15例正常皮肤组织(C组)中的表达,并进行统计学分析。结果I-TAC和MDC在A、B组中呈高表达,与C组比较其差异有统计学意义(P<0.01),但A、B组之间比较其差异无统计学意义(P>0.05)。结论I-TAC和MDC可能通过趋化T淋巴细胞定向迁移,引发一系列免疫炎性反应,从而促进病理性瘢痕的形成。Objective To study the expression of γ - IF - induced T - cell alpha chemoattractant （ I - TAC） and macrophage- derived chemokine （MDC） in pathological scar and explore their effect in formation of pathological scar. Methods Immunohistochemical techniques were used to measure the expression and distribution of I - TAC and MDC in 24 cases of keloid （group A）, 33 cases of hypertrophic scar （group B） and 15 cases of normal skin （group C）, and data were analyzed statistically. Results The expression of I - TAC and MDC in groups A and B was higher than that in group C and groups A and C showed a significant difference from group C （P 〈 0.01）. However, expression was not statistically different between group A and group B （ P 〉 0.05 ）. Conclusion I - TAC and MDC may enhance the formation of pathological scar via homing T helper （Th） lymphocytes which would result in immunoreactions.

关 键 词：I—TAC MDC 病理性瘢痕 

分 类 号：R622[医药卫生—整形外科]