紫杉醇磁性纳米脂质体动物体内分布及抑瘤效果研究  

In Vivo Distribution and Therapeutic Efficacy of Magnetic Liposomes Containing Paclitaxel for Lung Cancer in Nude Mice

作　　者：吴新荣[1] 刘志林[2] 辛胜昌[1] 

机构地区：[1]广州军区广州,总医院药学部,广州市510010 [2]广东外语外贸大学门诊部,广州市510420

出　　处：《中国药房》2008年第30期2336-2338,共3页China Pharmacy

摘　　要：目的:研究磁性纳米药物在动物体内的分布情况并考察其抑瘤效果。方法:尾静脉给予小鼠紫杉醇磁性纳米脂质体和紫杉醇脂质体,在磁性组体外施加0.5T的磁场,测定不同时间这2种药物在不同器官中的药物浓度;建立裸鼠肺癌模型,通过重量的变化比较几种药物的抑瘤效果。结果:紫杉醇磁性纳米脂质体组,在动物的肺部体外施加磁场,肺部位的药物浓度明显高于其它部位,且在给药后很快达到稳态浓度,而其它器官的药物浓度逐渐达到稳态浓度;紫杉醇脂质体组,给药后肺部位逐渐上升到稳态浓度。给予紫杉醇磁性纳米脂质体并施加磁场组的肿瘤抑制率为27.53%,显著高于紫杉醇脂质体组。结论:磁性靶向给药是一种有效的给药方式,可以将药物大量地聚集到靶部位,降低药物在正常器官的分布。OBJECTIVE： To investigate the distribution of magnetic nanoparticle embedding Paclitaxel in vivo and its curative effect on lung cancer in mice model.METHODS： The magnetic lipsomes containing Paclitaxel and the Paclitaxel liposomes were injected into caudal vein of mice, and which were exposed to magnetic field of 0.5T. The concentrations of the two drugs in different organs were determined .The lung cancer model was established in mice and the therapeutic efficacy of the different drugs on tumor was evaluated by comparing the weight of mice before and after administration, RESULTS： In the mice treated with magnetic liposome containing Paclitaxel, the drug concentration in lung which was exposed to magnetic field was significantly higher than that in the others sites, and a steady state concentration was reached quickly in lung after administration, but gradually in other organs. In the mice treated with liposomes containing paclitaxel, a steady state concentration was reached gradually in lung. The tumor control rate was 27.53% in mice treated with magnetic liposome containing Paclitaxel plus magnetic field intervention, significantly higher than in the control group. CONCLUSION： The result shows that magnetic targeting drug delivery is an effective drug delivery system, by which, the drugs can aggregate to the target site in large quantity which may lead to a reduced distribution of drugs in non - target sites.

关 键 词：紫杉醇 磁 靶向 癌 

分 类 号：R285.5[医药卫生—中药学] R979.1[医药卫生—中医学]