高乌甲素对S180荷瘤小鼠的免疫调节作用研究  

Immunoregulatory Effect of Lappaconitine in S180 Tumor-bearing Mice

作　　者：胡建楣[1] 陈凤仪[1] 

机构地区：[1]广州市番禺区人民医院药剂科,广州市511400

出　　处：《中国药房》2008年第30期2343-2344,共2页China Pharmacy

摘　　要：目的:研究高乌甲素(LA)对S180荷瘤小鼠的免疫调节作用。方法:每只小鼠腋窝皮下接种S180荷瘤生理盐水混悬液,24h后肌肉注射LA,每天给药1次,连续10d。检测S180荷瘤小鼠的免疫功能。结果:LA能显著升高S180荷瘤小鼠血清免疫球蛋白G(IgG)抗体水平;对2,4-二硝基氟苯诱导的迟发性超敏反应有增强作用;能诱导淋巴细胞转化为淋巴母细胞;能显著提高S180荷瘤小鼠网状内皮系统的吞噬功能;且能增强其红细胞免疫功能。结论:LA对小鼠S180荷瘤的生长具有抑制作用,能显著增强S180荷瘤小鼠的细胞免疫功能。OBJECTIVE： To study the immunoregularoty effect of Lappaconitine in S180 tumor- bearing mice. METHODS： Each mouse was inoculated hypodermically with S180 tumor cells and normal sodium suspension, 24 hours later, all the mice were injected i.m. with Lappaconitine q.d for 10 consecutive days. The immune function of the S180 tumor - bearing mice was detected. RESULTS： In Lappaconitine- treated mice, serum IgG level was heightened significantly; the 2, 4- DNFB-induced delayed type hypersensitivity was enhanced; the induction of transformation of lymphocytes into lymphoblast was achieved; the phagocytic function of reticuloendothelial system was enhanced significantly, and the immune function of red cells was promoted. CONCLUSION： Lappaconitine could inhibit the growth of S180 tumor cells and significantly enhance the cellular immune function of S180 tumor- bearing mice.

关 键 词：高乌甲素 细胞免疫功能 S180荷瘤小鼠 

分 类 号：R285[医药卫生—中药学] R96[医药卫生—中医学]