心身1号片对胃溃疡大鼠胃黏膜保护修复作用的探讨研究  

Study on protectve and reparing effect of "Xinshenyihao" in mucosa of rats with gastric ulcer

作　　者：白丽君[1] 贾锡莲[2] 武成[3] 刘志云 

机构地区：[1]天津医科大学,研究生天津300070 [2]天津医科大学总医院,天津300052 [3]天津市中医药研究院附属医院,天津300120 [4]天津市残疾人康复服务指导中心,天津300381

出　　处：《天津中医药》2008年第5期408-410,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市卫生局中医;中西医结合科研课题专项基金课题(2007023)

摘　　要：[目的]研究心身1号片(XS-1)抗实验性大鼠胃溃疡的药理作用及机制。[方法]用浸水—束缚应激法和醋酸烧灼法分别制作胃溃疡模型,观察心身1号片对胃溃疡的保护修复作用和对胃黏膜凋亡相关基因B细胞淋巴瘤/白血病基因-2(BcL-2)和BcL-2相关蛋白(Bax)表达的影响。[结果]XS-1对大鼠水浸应激性胃溃疡的形成有显著预防的作用(P<0.01);对乙酸烧灼性溃疡有显著治疗作用(P<0.01)。两组模型中,XS-1组Bcl-2阳性细胞数目较造模组增多,两者具有明显差异(P<0.01);造模组Bax阳性细胞数目较心身1号片组增多,两者具有明显差异(P<0.01)。[结论]中药XS-1能够促进溃疡大鼠胃黏膜组织Bcl-2的表达,降低Bax的表达,这可能是XS-1抗溃疡的作用机制之一。[Objective] To study the pharmacological action and mechanism of ＂Xinshenyihao＂（XS-1） in treating rats with experimental gastric ulcer. [Methods] Gastric ulcer was induced in rats by using soaking and restraining stress and acetic acid damage to study the function of XS-1 in protecting and repairing gastric ulcer, and the effect of XS-1 on the expression of Bcl-2 and Bax in rats with gastric ulcer was also determined. [Results] XS-1 played a significantly role in treating both acetic ulcer and in preventing stress ulcer. In both model groups, Bcl-2 positive cells in the XS-1 treated groups were significantly more than those in the model groups （P〈0.01）. In contrast,Bax positive cells in the model groups were significantly more than those in the XS-1-treated groups （P〈0.01）. [Conclusion] The traditional Chinese medicine Xinshenyihao can enhance the expresstion of Bel-2 and reduce the expresstion of Bax in mucosa of rats with gastric ulcer. This might be one of its mechanisms.

关 键 词：胃溃疡 凋亡 B细胞 淋巴瘤因子 X蛋白 心身1号片 

分 类 号：R285.5[医药卫生—中药学]