常咯啉对离体豚鼠心肌的电生理作用  

ELECTROPHYSIOLOGICAL EFFECTS OF CHANGROLIN ON ISOLATED PAPILLARY MUSCLES OF GUINEA PIG

作　　者：于海洋[1,2,3] 闫琳[1,2,3] 李汉青 王逸平[1,2,3] 

机构地区：[1]银川市第一人民医院心内科 [2]宁夏医学院药理教研室 [3]中国科学院上海药物研究所

出　　处：《宁夏医学院学报》1997年第4期1-3,60,共4页Journal of Ningxia Medical College

摘　　要：用豚鼠离体乳头肌观察了常咯啉（ＣＲＬ）对心肌收缩性、自律性、兴奋性和不应期的影响；用微电极技术进一步研究ＣＲＬ对动作电位及Ｖｍａｘ特性的影响，结果表明，ＣＲＬ具有负性肌力作用；可降低乳头肌自律性；延长功能性不应期；降低兴奋性；降低ＡＰＡ，缩短ＡＰＤ５０和ＡＰＤ９０；使ＥＲＰ／ＡＰＤ９０比值增大；对Ｖｍａｘ的抑制呈现浓度、频率和使用依赖性。当刺激频率为３Ｈｚ时，ＣＲＬ的起效速率为０．０４１±０．００７ＡＰ－１；恢复时间常数为１３６±２５ｓ。提示ＣＲＬ为慢动力型，属ＩＣ类抗心律失常药。We investigated the effects of changrolin (CRL) on action potential and some other physiological properties of guinea pig papillary muscle.CRL produced a dose dependent negatively inotropic action,depressed the abnormal automaticity elicited by adrenaline,prolonged functional refractory period and decreased excitability of papillary muscles.After being treated with CRL,the maximal upstroke velocity (max) and the action potential amplitude (APA) were decreased.The duration of action potential (APD) at 50% and 90% repolarization and the effective refractory period (ERP) were shortened,but the relative ratio of EPR/APD 90 was increased.The action of CRL on max showed an use and frequency dependent block.A train of stimuli of frequency ranged from 0.5 to 3.0 Hz led to an exponential decline in max. At 3.0 Hz,the onset rate of use dependent block were 0.041+0.007AP -1 . The time constant of the recovery of max from use dependent block were 136±25s.These results suggest that the CRL is a Na + channel blocker and a slow kinetic drug,and belongs to Ic type of anti arrhythmic drugs.

关 键 词：常咯啉 乳头肌 电生理学 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]