舒降之、力平之对老年人高脂血症的调节作用  

The Regulating Role of Simvastatin and Fenofibrate on the Elderly's Hyperlipemia

作　　者：全胜麟[1] 屈晓雯[1] 

机构地区：[1]云南省昆明市云南省第一人民医院内干科,昆明650032

出　　处：《中国医药导刊》2008年第6期869-869,875,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:了解舒降之、力平之对老年人血脂的调节作用和耐受性。方法:将147例老年高脂血症患者随机分为2组。分别予舒降之、力平之治疗8周。结果:舒降之降低总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)作用分别为28.43%、24.09%、36.53%,力平之降TC、TG、LDL-C作用分别为17.62%、47.29%。21.18%,两药升高高密度脂蛋白胆固醇(HDL-C)分别为4.35%与22.22%。结论:舒降之能明显降低TC、LDL-C水平,对TG有一定的作用,而力平之则相反,能显著降低TG水平,明显升高HDL- C。故对不同血脂水平的患者应用调脂药时应有侧重。老年人对两种调脂药均有良好的耐受性。Objective： To find out the effect and toleration of Simvastatin and Fenofibrate on the old patients Hyperlipemia. Method： 147 cases of old patients with Hyperlipemia were divided into two groups： the Simvastatin treatment group and the Fenofibrate treatment group. All of the patients were treated 8 weeks. Results： The rate of reducfon, Simvastatin treatment group,TC：28.43%,TG：24.09%,LDL- C：36.5%; Fenofibrate treatment group TC：17.62%, TG：47.92%, LDL-C：21.18%, and the rate of rise, Simvastatin treatment group, HDL- C： 4.35%, Fenofibrate treatment group, HDL-C： 22.22%. Conclusions： Simvastatin can reduce TC and LDL-C evidently, reduce TG certainly. Fenofibrate can reduce TG evidently, but increase HDL-C evidently too. So treating patients with different blood-fat level should use different method. Both Simvastatin and Fenofibrate had well- toleration for old patient.

关 键 词：商脂血症 舒降之 力平之 

分 类 号：R589.2[医药卫生—内分泌]