类风湿性关节炎患者抗CCP和抗RA33抗体检测的临床意义  

The Clinical Significance of Detecting Anti-CCP and Anti-RA33 Antibodies for Rheumatoid Arthritis Patients

作　　者：王丽萍 韩丙遵 王洪英 赵逸 

机构地区：[1]山东省高密市中医院,261500

出　　处：《中国医药导刊》2008年第6期914-915,916,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨环瓜氨酸多肽(CCP)抗体和RA33抗体对类风湿性关节炎(RA)的临床应用价值。方法:对47例RA患者、25例未分化关节炎患者、29例其他自身免疫病患者分别采用ELISA法检测CCP抗体、RA33抗体,速率散射比浊法检测CRP、类风湿因子(RF)、抗链球菌溶血素O(ASO),魏氏法检测红细胞沉降率(ESR),观察各指标对RA的诊断及治疗价值。结果:RA患者抗CCP抗体、抗RA33抗体以及RF的敏感性分别为63.8%、44.7%和93.6%,特异性为93.1%、89.6%和68.9%;两种抗体对未分化关节炎诊断为RA的确诊率为63.6%、55.6%。CRP与ESR有良好的相关性,与ASO一起可作为RA患者病情监控的指标。结论:CCP抗体、RA33抗体有助于RA的诊断及早期诊断,而各项指标的联合检测对RA诊断、鉴别诊断、治疗观察、病情估计和判断预后均有重要意义。Objective： To investigate clinical value of cyclic citrullinated peptide （CCP） antibodies and RA33 antibodies on rheumatoid arthritis （RA）.Method： 47 cases of RA patients, 25 patients with undifferentiated arthritis patients, 29 patients with other autoimmune disease were detected by ELISA CCP antibody, RA33 antibodies, the rate of scattering of Nephelometry testing CRP, rheumatoid factor （RF）, anti-chain Hemolytic streptococcus-O （ASO）, Wei was detected erythrocyte sedimentation rate （ESR.）, observation of the targets on the diagnosis and treatment of RA value. Results： RA patients anti-CCP, anti-RA33 antibodies and the sensitivity of RF were 63.8%, 44.7% and 93.6% and specificity of 93.1%, 89.6% and 68.9%; two antibody on the undifferentiated arthritis diagnosis of the RA Diagnosis rate was 63.6%, 55.6%. CRP and ESR a good correlation, together with the ASO can be used as RA patients with monitoring indicators. Conclusions： CCP antibody, RA33 antibodies contribute to the RA diagnosis and early diagnosis, and the targets of the joint detection of RA diagnosis, differential diagnosis and treatment of illness and prognosis are estimated significance.

关 键 词：类风湿性关节炎 环瓜氨酸多肽抗体 RA33抗体 C反应蛋白 诊断 治疗 

分 类 号：R593.22[医药卫生—内科学]