TGF-β_1在IgA肾病中的作用  

The Role of Transforming Growth Factor-β_1 in Immunoglobulin A Glomerulonephritis

作　　者：周莹[1] 吕吟秋[1] 

机构地区：[1]温州医学院附属第一医院肾内科,浙江温州32500

出　　处：《医学综述》2008年第20期3072-3075,共4页Medical Recapitulate

摘　　要：转化生长因子β1(TGF-β1)被认为是最重要的促纤维化因子之一。在IgA肾病中,一方面它能增加细胞外基质的合成并抑制其降解,从而导致肾小球硬化;另一方面它可调节肾小管上皮细胞向间充质细胞转化,从而导致肾间质纤维化。血管紧张素转化酶抑制剂和血管紧张素受体抑制剂不能完全阻断TGF-β1的表达。修饰素cDNA注入骨骼肌内可阻止纤维化进程,有可能成为治疗肾脏纤维化疾病的有效药物。Transforming growth factor-betal （TGF- β1） is a major cause of tissue fibrosis. In hu- man immunoglobulin A glomerulonephritis（IgAN） ,TGF- β1 can promote the ceils to synthesis and se- crete extracelluar matrix. The excessive accumulation of extracelluar matrix will cause glomerttlar sclero- sis. On the other hand,TGF- β1 promotes the renal tubular epithelial celt transform to the mesenchymal cell ,which causes interstitial fibrosis of renal interstitium. Angiotensin-converting enzyme inhibitor and angiotensin receptor inhibitor cannot block the expression of TGF- β1. Decorin cDNA is transferred into the skeletal muscle in order to prevent the renal tubulointerstitial fibrosis development,which will be a active drug in the future.

关 键 词：转化生长因子Β1 IGA肾病 肾小球硬化 间质纤维化 

分 类 号：R692[医药卫生—泌尿科学]