慢性阻塞性肺疾病的气道反应性与血清IL-8因子水平的研究  

STUDY ON NATURE OF BRONCHIAL HYPERRESPONSIVENESS AND IL-8 SERUM LEVEL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

作　　者：项阳[1] 韩清韶[1] 

机构地区：[1]广东医学院附属医院呼吸内科

出　　处：《广东医学院学报》1997年第4期336-338,共3页Journal of Guangdong Medical College

摘　　要：目的：探讨慢性阻塞性肺疾病（COPD）的气道反应性及IL－8因子在COPD发病中的作用。方法：用组胺气过吸入激发试验观察缓解期COPD、哮喘和健康人的气道反应性，同时测定气道激发前后血清IL－8水平变化。结果：COPD和哮喘患者均呈气道高反应性，且COPD组PD20FEV1与FEV1／Pre％呈显著正相关（r＝0．418，P＜0．01）；缓解期COPD和哮喘息者血清IL－8水平均显著高于正常对照组（P＜0．02，P＜0．05），IL－8水平与PD20FEV1无显著相关性；气道激发后COPD和哮喘血清IL－8均较激发前下降，COPD组差异不显著（P＞0．05），哮喘组差异显著（P＜0．02）．结论：气道高反应性可能是COPD的特征之一，IL－8在COPD和哮喘的发病过程中起重要作用，并可能是缓解期的抗炎性细胞因子。Objective:To investigate the nature of bronchial responsiveness in patients with COPD and the effect of IL-8 on the pathogenesis of COPD. Methods:The airway rpactivity in subjects with COPD is studied by a bistamine inhalation test(HIT) compared with asthmatic patients and normal individuals.and the IL-8 serum concentration was determined by ELISA be fore and after HIT. Results :Both COPD and asthmatic patinets demonstrated bronchial hyperresponsiveness(BHR),and there was a positive cor-relation between the values of PD50FEV1 and FEV1/Pre % in COPD patients (r= 0. 418,P<0. 01). Sig-nificantly increased IL-8 level was found in the patients with stable COPD and asthma compared with that of the controls (P< 0.02, P< 0. 05, respectively), but there was no correlation between the in-creased IL-8 concertration and PD20FEV1 after HIT the IL-8 content in. patients with COPD and asthma decreased but not signifaicantly with CQPD (P>0. 05);and significantly with asthma(P<0. 02). Con-clusion: BHR seems to be a characteristic of COPD and IL-8 may play an important role in the pathogen-esis of COPD and asthma,and it rnay also be an anti-inflammatory cytokine in stable COPD and asthma.

关 键 词：肺疾病 阻塞性肺疾病 气道反应性 白细胞介素8 

分 类 号：R563.02[医药卫生—呼吸系统]