5-羟甲基噻唑合成工艺的研究  

Study on Synthesis Process of 5-Hydroxymethylthiazole

作　　者：陈岚 曾平 

机构地区：[1]长沙环保职业技术学院,湖南长沙410004 [2]湖南轻工研究院,湖南长沙410015

出　　处：《化工中间体》2008年第10期13-15,共3页

摘　　要：以2-氯-5氯甲基噻唑为主要原料,经酯化、还原、水解三步反应后合成5-羟甲基噻唑。以醋酸和锌粉为还原材料,采用催化剂使还原反应在常压和较低温度下进行。三步反应总收率达到54%,产品纯度在98%以上。探讨了酯化时间、催化剂用量、水解温度和时间等因素对收率的影响。5-hydroxymethylthiazole was synthesised from 2-chloro-5-chloromethyl-thiazole as the main raw material after the three steps of esterification, reduction, and hydrolysis reaction. Use the zinic powder and acetate as the reductional activator, the reduction can be carried through in atmospheric pressure and lower temperature with the catalyst added in. The over all yield of the three-step reaction is 54%, and the purity of the product is over 98%. time, amount of catalyst, hydrolysis temperature and time on the yield was The effect of esterification discussed.

关 键 词：5-羟甲基噻唑 2-氯-5氯甲基噻唑 三步反应 合成 

分 类 号：TQ460.4[化学工程—制药化工]