烧伤脓毒症发病机制与防治对策  

The pathogenesis and management of severe sepsis after burns

作　　者：姚咏明[1] 盛志勇[1] 柴家科[1] 

机构地区：[1]解放军总医院第一附属医院全军烧伤研究所,北京100037

出　　处：《中华烧伤杂志》2008年第5期337-339,共3页Chinese Journal of Burns

基　　金：国家重点基础研究发展规划（G1999054203-2、2005CB522602）;国家杰出青年基金（30125020）;国家自然科学基金（30672178、30200293、39870286）

摘　　要：脓毒症指由感染引起的全身炎性反应综合征，证实有细菌存在或有高度可疑感染灶。脓毒症是创伤、烧伤、休克、大手术等临床急危重患者的严重并发症之一，进一步发展可导致脓毒性休克、多器官功能障碍综合征（MODS），系当前烧伤外科面临的棘手难题，已成为提高临床危重患者救治成功率的主要障碍。因此，深入了解脓毒症的发病机制及其可能防治策略具有重要意义。Sepsis and septic shock as a result of an invasive infection are challenging problems in extensively burned patients, and frequently end in multiple organ dysfunction syndrome （MODS）. It is of great significance to further elucidate the pathogenetic mechanisms, and to seek novel intervention strategies to prevent and treat sepsis/MODS secondary to severe burns. A more complete understanding of the pathogenetic mechanisms of postburn sepsis would certainly elicit a number of potential therapeutic strategies for it. It is our belief that comprehensive clinical measures for management of severe sepsis should include rapid, adequate fluid resuscitation for burn shock, early feeding, effective control of infection, early eseharectomy, and reinforcement of organ support. Once burn wound sepsis occurs, prompt removal of infected necrotic tissue is the key procedure to ensure a successful result. Further study is necessary to determine the precise mechanisms of these protective effects and the clinical advantages for postburn sepsis using evidence-based methodology system.

关 键 词：烧伤 脓毒症 多器官功能衰竭 抗生素预防 

分 类 号：R459.7[医药卫生—急诊医学]