纳米羟基磷灰石/聚酰胺66多孔材料制备和生物安全性初步评价  

Preparation and Biological Safety Evaluation of Porous n-HA/PA66 Composite

作　　者：李鸿[1,2] 李玉宝[1] 严永刚[1] 周刚[1,2] 王明波[1,2] 程琳[1,2] 

机构地区：[1]四川大学纳米生物材料研究中心分析测试中心,成都610064 [2]四川大学化学学院,成都610064

出　　处：《生物医学工程学杂志》2008年第5期1126-1129,共4页Journal of Biomedical Engineering

摘　　要：采用注塑方法,以医用纳米羟基磷灰石/聚酰胺66(n-HA/PA66)复合材料为原料,使用专用发泡剂,制备出了一种具有贯通孔,平均孔隙尺寸约为500μm的多孔材料,并参照GB/T16886和GB/T16175标准方法,对其生物安全性进行了相关评价。细胞毒性试验、致敏试验、热原试验和溶血试验结果表明本研究制备的多孔n-HA/PA66复合材料无细胞毒性、无致敏性、无热原反应,溶血率为0.59%(<5%),可初步认为n-HA/PA66多孔材料具有良好的生物安全性,可用于骨组织修复。Porous nano-hydroxyapatite/polyamide 66 （n-HA/PA66） composite was developed by injection molding method. Uniformly distributed and interconnected pores with an average size of about 500μm in matrix were obtained. The evaluation of biological safety of the porous composite including cell cytoxicity test, sensitivity test, pyrogen test, haemolysis test was carried out according to GB/T16886 and GB/T16175. The results showed that the porous n-HA/ PA66 composite was of no cytotoxicity, no allergen and pyrogen reactions as well as no hemolytic effect.

关 键 词：N—HA/PA66 多孔材料 生物安全性 评价 

分 类 号：TB383.4[一般工业技术—材料科学与工程]