纳米羟基磷灰石骨修复复合材料的研究进展  

Development of Nanohydroxyapatite Composites as Bone Grafting Materials

作　　者：王瑞芳[1] 文达[1] 谢兴益[1] 钟银屏[1] 

机构地区：[1]四川大学高分子科学与工程学院,成都610065

出　　处：《生物医学工程学杂志》2008年第5期1231-1234,共4页Journal of Biomedical Engineering

摘　　要：羟基磷灰石(Hydroxyapatite,HA)是一种性能良好的骨修复材料,但是由于脆性而限制了它在承力部位的应用。天然骨本身是纳米羟基磷灰石(Nanohydroxyapatite,n-HA)和胶原的复合材料,从仿生的角度看,n-HA与其它材料复合可以提高生物相容性和力学性能。目前研究的纳米羟基磷灰石复合材料可分为两类:非降解的纳米羟基磷灰石复合材料和可降解的纳米羟基磷灰石复合材料。前者包括n-HA/聚乙烯、n-HA/尼龙以及n-HA/聚丙烯酸。后者主要有n-HA与胶原、明胶、壳聚糖、聚乳酸和聚酸酐等的复合材料。本文详细综述了近年来纳米羟基磷灰石复合材料的制备、力学性能以及生物学性能的研究进展。Hydroxyapatite （HA） is one of ideal materials for bone substitutions due to its intrinsic biocompatibility. However, its relatively poor mechanical properties such as brittleness and low strength have hindered its use in high-load applications. Biotic bones themselves are nanccomposites mainly composed of nanohydroxyapatite （n-HA） and collagen. From biomimetic point of view, nanocomposites of HA could potentially improve both biocompatibility and mechanical properties of bone grafting materials. Recent progress in this field branched into nanocomposites of HA with nonbiodegradable and biodegradable polymers, the latter including collagen, gelatin, chitosan, polylactides as well as polyanhydrides. In this paper, the preparation, biological reactions and mechanical properties of different nanocomposites are reviewed in detail.

关 键 词：纳米羟基磷灰石 纳米复合材料 骨修复材料 

分 类 号：R318.08[医药卫生—生物医学工程]