Mohnarin 2006～2007年度报告:东北地区细菌耐药监测  

2006～2007 Mohnarin report:Bacterial distribution and resistance in north east China

作　　者：褚云卓[1] 田素飞[1] 张智杰[2] 崔连东[3] 陈淑兰[4] 张和光[5] 徐雪松[6] 许建成[7] 范艳萍 佟忠山 

机构地区：[1]中国医科大学附属第一医院,沈阳110001 [2]中国医科大学附属第二医院,沈阳110001 [3]辽宁省人民医院,沈阳110001 [4]哈尔滨医科大学一附院,哈尔滨150001 [5]哈尔滨医科大学二附院,哈尔滨150086 [6]吉林大学中日联谊医院,长春130033 [7]吉林大学第一医院,长春130021 [8]大连中心医院,大连116000 [9]黑龙江省人民医院,哈尔滨150001

出　　处：《中国抗生素杂志》2008年第10期640-646,共7页Chinese Journal of Antibiotics

摘　　要：目的调查分析东北地区2006-2007年临床分离细菌对抗菌药物的耐药性。方法2006年6月1日-2007年5月31日，东北地区9家医院收集临床分离细菌，并进行药敏试验，结果依据2006年CLSI标准，采用WHONET5．4软件进行统计分析。结果9195株细菌中革兰阴性菌6814株，占74．1％，革兰阳性菌2381株，占25．9％。大肠埃希菌、肺炎克雷伯菌和奇异变形菌ESBLs的发生率分别为43．7％、38．3％和7．0％。MRSA和MRCNS检出率分别为64．8％和76．5％，未检测到万古霉素耐药株，也未发现万古霉素、替考拉宁耐药的粪肠球菌和屎肠球菌。亚胺培南对肠杆菌科细菌仍保持较高的敏感性（〉94％）。大约68％的大肠埃希菌对环丙沙星及左氧氟沙星耐药。铜绿假单胞菌对头孢哌酮／舒巴坦耐药性最低（19．7％），其次是阿米卡星、环丙沙星、头孢他啶、亚胺培南和头孢噻肟（21．4％～31．3％）；鲍曼不动杆菌对亚胺培南敏感率可达84．4％。结论对细菌耐药性应引起足够重视，加强抗菌药物合理使用以降低耐药性，并采取有效措施控制其传播。Objective The aim of this study was to investigate the antibiotic resistance in clinical isolates in 2006-2007. Methods From June 1 2006 to May 31 2007, consecutive and non-repetitive clinical isolates were collected in 9 hospitals from northeast region, and antimicrobial susceptibility testing was carried out. The data were analyzed by WHONET 5.4 software. Results Of the 9195 clinical isolates collected, 74.1% were Gram-negative bacilli and 25.9% were Gram-positive cocci. About 64.8% of Staphylococcus aureus were methicillin-resistant （MRSA）, and 76.5% of coagulase negative Staphylococcus isolates were methicillin-resistant （MRCNS）. No vancomycin or teicoplanin-resistant isolates were found in Staphylococcus, Enterococcus faecal and Enterococcus faecium. The prevalence of extended-spectrum β-1actamases （ESBLs） was 43.7% in E. coli, 38.3% in K. pneumoniae and 7.0% in Proteus mirabilis. About 68% of E. coli isolates were resistant to ciprofloxacin and levofloxacin. Imipenem was the most potent antimicrobial agents against Enter-obacteriaceae （〉94 %）. The lowest resistance rate of P. aeruginosa was 14.7% （cefoperazone/sulbactam）, followed by amikacin, ceftazidime, ciprofloxacin, cefotaxime and imipenem （21.4%-31.3%）, while more than 84.4% of the A. baumannii isolates were susceptible to imipenem. Conclusions It was very important to rationally use antimicrobial agents and take effective measures for the control of the spread of resistant isolates.

关 键 词：MOHNARIN 中国东北地区 细菌耐药性监测 2006-2007年 

分 类 号：R378[医药卫生—病原生物学]