非小细胞肺癌PET-CT标准摄取值与葡萄糖转运蛋白1和微血管密度及Ki67表达的相关性  

Correlation between SUV of ^18F-FDG PET-CT and the expression of GLUT1, MVD and Ki67 in non-small cell lung cancer

作　　者：段钰[1] 于丽娟[1] 陆佩欧[1] 王文志[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院PET—CT中心,150081

出　　处：《中华肿瘤杂志》2008年第10期764-767,共4页Chinese Journal of Oncology

基　　金：黑龙江省教育厅2007年度科学技术研究面上资助项目（11521175）

摘　　要：目的分析非小细胞肺癌（NSCLC）^18F-氟代脱氧葡萄糖（^18F—FDG）标准摄取值（SUV）与葡萄糖转运蛋白1（GLUT1）、微血管密度（MVD）及Ki67表达的相关性。方法收集经^18F—FDGPET-CT检查并手术切除的NSCLC33例，采用免疫组织化学SP法，分别检测GLUT1、MVD和Ki67，并将三者与^18F—FDG的SUV进行对比。结果33例NSCLC患者中，Ⅰ期21例，Ⅱ期4例，Ⅲa期8例。33例NSCLC标本中，GLUT1阳性者22例（12例腺癌，10例鳞癌），阴性者11例（10例腺癌，1例鳞癌），阳性率为66．7％；Ki67阳性者24例（13例腺癌，11例鳞癌），阴性者9例（均为腺癌），阳性率为72．7％；CD34阳性者33例，阳性率为100．0％，标本平均MVD为（12．6±2．9）条，33例NSCLC的SUV为1．4～27．4，中位数为10．1。结论 ^18F—FDG PET的SUV与GLUT1呈线性相关，SUV与Ki67表达和MVD无相关性。GLUT1、Ki67和CD34与病灶大小及有无淋巴结转移无相关性。Objective To investigate the correlation between ^18F-FDG standard uptake value （SUV） and expression of GLUTI, MVD and Ki67 in non-small cell lung cancer （NSCLC）. Methods Thirty-three patients with non-small cell lung cancer received preoperative ^18F-FDG PET-CT examination and underwent surgery. The expression of GLUT1, MVD and Ki67 were detected by immunohistochemstry. The correlation between the SUV of ^18F-FDG PET-CT and the immunohistochemical results of the three above mentioned parameters was analyzed. Results Of the 33 NSCLC patients, 21 were in stage Ⅰ , 4 in stage Ⅱ and 8 in stage Ⅲ a. Positive expression of GLUT1 was found in 22 cases （66.7% , 12 adenocarcinomas and 10 squamous cell carcinomas）, and negative expression in 11 cases （10 adenocarcinomas and 1 squamous cell carcinoma）. Twenty-four patients （72.7%） showed positive expression of Ki67 （ 13 adenocarcinomas and 11 squamous cell carcinomas ）, and other 9 （adenocarcinomas） had negative expression. The positive expression rate of CD34 in this series was 100.0% with a mean MVD of 12.6 ± 2.9. Conclusion SUV of ^18F-FDG PET-CT is linearly correlated with the expression of GLUT1, but not with the expression of Ki67 or MVD. The expression of GLUT1, Ki67 and CD34 is not correlated with tumor size and lymph node metastasis.

关 键 词：肺肿瘤 PET-CT ^18F-氟代脱氧葡萄糖 标准摄取值 肿瘤分子生物学指标 

分 类 号：R686[医药卫生—骨科学]