广东省重要岛屿恙虫病东方体血清流行病学调查  

Seroepidemiological investigation on Orientia tsutsugamushi of the important South-Sea islands of Guangdong Province,China

作　　者：李珉珉[1] 王珊珊[2] 李健[3] 刘金华[2] 苏建新[2] 唐博恒[2] 李曦[2] 

机构地区：[1]暨南大学附属第一医院临床检验中心,广东广州510630 [2]广州军区疾病预防控制中心,广东广州510507 [3]解放军第四二一医院,广东广州510318

出　　处：《中国病原生物学杂志》2008年第10期743-744,753,共3页Journal of Pathogen Biology

基　　金：广东省自然科学基金项目(No.7004992)

摘　　要：目的在广东省5岛屿开展恙虫病东方体血清流行病学调查并进行血清分型,为制定恙虫病防治策略提供依据。方法1998年5月～2003年8月在广东省南澎列岛、南澳岛、万山群岛、硇洲岛和雷州半岛等岛屿采集驻岛官兵、居民及啮齿动物血清,采用免疫荧光法检测抗体并进行血清学分型。结果687份人血清中抗恙虫病抗体阳性95份,阳性率13.83%,其中岛屿居民抗体阳性率为26.91%,军人为3.63%,差异有统计学意义(P<0.05)。检测508份鼠血清,抗恙虫病东方体抗体阳性率为57.87%,其中褐家鼠为有时鼠种。恙虫病东方体血清型以Karp株为主,占50.90%。结论广东省5岛屿均为恙虫病疫源地,恙虫病东方体血清型以Karp株为主。Objective To establish strategies for preventing Orientia tsutsugamushi infection in the important South-Sea islands of Guangdong Province,seroepidemiological investigation of anti-O, tsutsugamushi antibodies was determined. Methods Sera were collected from soldiers, residents and rodents from the areas of Nanpenglie islands, Nan＇ao island, Wanshan archipeiago, Naozhou island and Leizhou peninsula, located in the Guangdong Province of China from May 1998 to August 2003. lmmunofluorescence assay （IFA） was used for serotyping. Results Among the 687 human sera, 95 were positive of anti-O, tsutsugamushi antibodies, with a positive rate of 13. 83%. The positive rate of residents （26.91%） was significantly higher than that of soldiers （3. 63%）. Among the 508 rodents＇ sera from the above five islands, the positive rate of anti-O, tsutsugamushi antibodies was 57.87% and the highest rate was seen in Rattus norvegicu. Serotyping showed the main antigen type of O. tsutsugamushi on those islands was Karp strain, with a percentage of 50.90%. Conclusion High positive rates of anti-O, tsutsugamushi antibodies has been seen in human and rodents sera collected from the five important islands of Guangdong Province. Furthermore, Karp stain is the main antigen type by se roepidemiological investigation. These results show that these islands are epidemic areas of Tsutsugamushi disease. Prevention strategies should be taken to decrease the positive rate in order to avoid large epidemic of Tsutsugamushi disease.

关 键 词：南海岛屿 恙虫病 恙虫病东方体 血清流行病学 

分 类 号：R532.39[医药卫生—内科学]