配合物[Co(C_(13)H_(16)N_2O_7S_2)(H_2O)_3]_2·H_2O的体外抗菌活性研究  

Study of the antibacterial activities of the complex [Co(C_(13)H_(16)N_2O_7S_2)(H_2O)_3]_2·H_2O

作　　者：秦秀英[1] 陈素一[1] 

机构地区：[1]桂林医学院药学院,广西桂林541004

出　　处：《华夏医学》2008年第4期630-631,共2页Acta Medicinae Sinica

摘　　要：目的:对标题化合物Co()-牛磺酸缩-5-甲基-2-羟基-1,3-苯二甲醛席夫碱配合物[Co(C13H16N2O7S2)(H2O)3]2.H2O进行体外抗菌活性研究。方法:采用连续稀释法测定该化合物对金黄色葡萄球菌、乙型溶血性链球菌、肺炎链球菌和大肠杆菌的最低抑菌浓度。结果:该化合物在浓度为0.5325 mg/ml时,对肺炎链球菌无菌落生长,而对金黄色葡萄菌、乙型溶血性链球菌和大肠杆菌都有菌落生长。结论:该化合物对肺炎链球菌有体外抗菌活性,其MIC值为0.5325 mg/ml,而对金黄色葡萄球菌、乙型溶血性链球菌和大肠杆菌都无体外抗菌活性。Objective：To explore the title complex Co（ Ⅱ ）-taurine-5-methyl-2-hydroxyisophthalaldehyde Schiff Bases [Co（C13H16N2O7S2） （H2O）3]2· H2O for the antibacterial activities via the antimicrobial test in vitro. Methods：Using the serial dilution test, the title complex was confirmed the minimal inhibitory concentration for S. aureus, hemolytic streptococcus, S. pneumoniae and E. coli, respectively. Results：The antibacterial property experiment showed that the complex could be the antibacterial activity for the S. pneumoniae and not for S. aureus,β-hemolytic streptococcus and E. coli when the concentration was 0. 5825 mg/ml. Conclusion ：The title complex shows the antibacterial activity for the S. pneumoniae and not for S. aureus, β-hemolytic streptococcus and E. coli and the minimal inhibitory concentration for the S. pneumoniae is 0. 5325 mg/ml.

关 键 词：Co(Ⅱ) 牛磺酸缩-5-甲基-2-羟基-1  3-苯二甲醛席夫碱 抗菌活性 

分 类 号：R962[医药卫生—药理学] R965[医药卫生—药学]