Effects of dauricine,quinidine,and sotalol on action potential duration of papillary muscles in vitro  

作　　者：郭东林[1] 曾繁典[1] 胡崇家[1] 

机构地区：[1]同济医科大学临床药理研究所

出　　处：《中国药理学报》1997年第4期348-350,共3页Acta Pharmacologica Sinica

摘　　要：目的：观察蝙蝠葛碱对豚鼠乳头状肌的动作电位是否具有使用依赖性特征，并与奎尼丁、索他洛尔作平行比较．方法：利用细胞内微电极技术记录豚鼠乳头状肌跨膜动作电位．结果：蝙蝠葛碱２０μｍｏｌ·Ｌ－１能明显延长乳头状肌跨膜动作电位时程，在刺激周长为２００，３００，４００，６００，８００，１０００，２０００ｍｓ时，其延长动作电位时程的百分率分别为２２±８，１１±６，９±５，７±５，６±３，４３±２８，４５±２８，蝙蝠葛碱延长动作电位时程作用于刺激周期较短时作用明显，呈使用依赖性特征．而奎尼丁１μｍｏｌ·Ｌ－１和索他洛尔１０μｍｏｌ·Ｌ－１延长动作电位时程作用随刺激周期延长而增强，呈现逆向使用依赖性特征．结论：蝙蝠葛碱使用依赖性延长豚鼠乳头状肌动作电位时程．IM: To compare the characteristics of dauricine, sotalol, and quinidine on action potential duration (APD). METHODS: Using intracellular micro-electrode method to record APD in guinea pig papillary muscles. RESULTS: Dauricine 20 μmol ·L -1 prolonged action potential at 90 % repo￣lariza￣tion, the percent of APD prolongation were 22±8, 11±6, 9±5, 7±5, 6±3, 4 3±2 8, 4 5±2 8 at the cycle lengths of 200-2000 ms, dauricine became more effective in lengthening APD at short cycle lengths. The effect of dauricine on prolonging APD exhibited normal use dependence, whereas quinidine 1 μmol·L -1 and sotalol 10 μmol ·L -1 were less effective in lengthening APD at short cycle lengths. The effect of quinidine and sotalol on APD exhibited reverse use dependence. CONCLUSSION: The effect of dauricine on APD depends on activation frequency.

关 键 词：蝙蝠葛碱 硅尼丁 索他洛尔 乳头状肌 

分 类 号：R972.2[医药卫生—药品]