恩诺沙星残留对土壤细菌耐药性的影响  

Impact of enrofloxacin on antimicrobial susceptibilities of soil bacteria

作　　者：马驿[1] 陈杖榴[2] 

机构地区：[1]广东海洋大学动物医学系,广东湛江524088 [2]华南农业大学兽医学院广东省兽药研制与安全评价重点实验室,广东广州510642

出　　处：《中国兽医杂志》2008年第10期9-11,共3页Chinese Journal of Veterinary Medicine

基　　金：国家自然科学基金重点资助项目"兽药及添加剂残留毒性与生态毒理研究"(30130140)

摘　　要：兽药吸收进入动物机体后，少部分药物将残留于动物组织细胞内，而大部分药物将排泄出体外，最终进入生态环境中，且可能造成环境污染。为了了解恩诺沙星在环境中残留对土壤细菌耐药性的影响，本试验采用琼脂稀释法对土壤细菌进行了抗菌药物敏感性试验。结果表明，恩诺沙星对用药前分离的土壤优势细菌的MIC值都比较低，为0．008-2μg／mL，对其中大多数细菌的MIC值为0．032-0．125μg／mL；用药后分离的土壤细菌对恩诺沙星的敏感性降低，细菌对恩诺沙星的耐药率和耐药水平随土壤中药物浓度加大和时间的延长而明显增高。It has been known that part of their parents and metabolites of veterinary drugs will be remained in animal tissues, but most of them are excreted out from the animal body and enter into soil which may bring about environmental problems when the drugs are absorbed and transferred throughout the body. The antimicrobial susceptibilities of soil bacteria were examined by the agar dilution method before and after the enrofloxacin （ENR） was added to soils to study the effect of ENR on soil bacteria. The resuits showed that the minimum inhibitory concentration （MIC） of the dominant bacteria were 0. 008 - 2 μg/mL, and most of them were 0. 032-0. 125 μg/mL before the ENR was added to the soil. However, most of the bacteria manifested the different degrees of resistance to ENR after it was added to the soil. The growth rate and resistant degree of ENR-resistant bacteria were enhanced with the increase of ENR concentrations in soil and treatment time.

关 键 词：恩诺沙星 残留 耐药性 土壤细菌 

分 类 号：S859.79[农业科学—临床兽医学]