血清PSA、游离PSA与良性前列腺增生临床的相关性研究  

Clinical study on the correlation between serum PSA,free PSA and benign prostatic hyperplasia

作　　者：李明[1] 吴斌[1] 宋永胜[1] 王颖[2] 霍军[1] 郭恩忠[1] 殷波[1] 

机构地区：[1]中国医科大学附属盛京医院泌尿外科,沈阳110004 [2]中国医科大学附属第一医院核医学科

出　　处：《中国男科学杂志》2008年第9期37-39,共3页Chinese Journal of Andrology

摘　　要：目的分析血清前列腺特异性抗原(PSA)及游离前列腺特异性抗原(fPSA)与良性前列腺增生(BPH)临床的相关性。方法应用化学发光微粒子免疫分析法(CMIA)对BPH患者血清PSA、fPSA进行检测。结果入选的40例患者病理均为BPH。PSA>4ng/ml者,术后随访1～3个月,平均2.5个月,PSA值均降至0.02ng/ml以下,可除外前列腺癌(PCa)病例。PSA<4ng/ml者16例(40%),4～10ng/ml者14例(35%),>10ng/ml者10例(25%);fPSA>0.934ng/ml者22例(55%)。血清PSA、fPSA水平与前列腺总体积(PV)、前列腺移行区体积(TZV)、年龄及国际前列腺症状评分(IPSS)呈正相关。结论本组血清fPSA与PV、TZV、年龄、IPSS评分有更强相关性。BPH患者血清PSA、fPSA水平升高的相关因素与前列腺总体积及移行区增大、高龄及高IPSS评分有关。Objective To evaluate the clinical relationship between serum prostate specific antigen（PSA）, free PSA level and benign prostatic hyperplasia（BPH）. Methods The value of serum PSA and free PSA in patients with BPH were determined by the Chemiluminesent Microparticle Immun- oassay （CMIA）. Results Benign prostatic hyperplasia patients were all confirmed by pathological analysis.For the patients with the serum PSA level over 4ng/ml, their PSA level decrease to 0.02ng/ml at average 2.5 months after operation,hence prostatic carcinoma case can be excluded. The levels of serum PSA in 16 cases（40%）was less than 4ng/ml,14 cases（35%） 4-10ng/ml,and 10 cases（25%） over 10ng/ml; the level of serum free PSA of 22 cases（55%） were over 0.934ng/ml.There was a positive correlation between the level of serum PSA/free PSA and PV, TZV, age, IPSS. Conclusion The serum free PSA compare to the PSA showed a stronger relationship with PV,TZV,age, IPSS. Enlarged prostate volume, transition zone volume, older age and high IPSS scores considered to be the main causes leading to elevated PSA and free PSA level in BPH patients.

关 键 词：良性前列腺增生 前列腺特异性抗原 游离前列腺特异抗原 化学发光微粒子免疫分析 

分 类 号：R697.32[医药卫生—泌尿科学] R321.1[医药卫生—外科学]