^(188)Re-DTPA-DG内照射吸收剂量的估算  

ESTIMATION OF THE ABSORBED DOSE OF ^(188)RE-DTPA-DG INTERNAL RADIATIONVIA

作　　者：陈跃[1] 黄占文[1] 李蓓蕾[2] 熊青峰[1] 何菱[3] 

机构地区：[1]泸州医学院附属医院核医学科,四川泸州646000 [2]复旦大学附属中山医院核医学科 [3]四川大学华西药学院

出　　处：《泸州医学院学报》2008年第5期487-489,共3页Journal of Luzhou Medical College

基　　金：国家自然科学基金(30670582);四川省科技厅应用基础基金(2006J13-032)

摘　　要：目的:估算188Re-DTPA-DG(二乙三胺五乙酸-脱氧葡萄糖)肿瘤治疗中肿瘤和主要器官内照射吸收剂量。方法:荷MCF-7乳腺癌裸鼠尾静脉注射后,在3、12、24h处死动物,测定小鼠体内各脏器放射性分布,换算至标准人体内分布数据,按MIRD法计算188Re-DTPA-DG全身、肿瘤和各主要器官的平均总吸收剂量。结果:肿瘤辐射剂量为255.32mSv/MBq,其他脏器内照射吸收剂量在0.002～6.850mGy/MBq之间,有效剂量为1.420±0.043mSv/MBq。结论:188Re-DTPA-DG可以作为临床上肿瘤治疗和诊断药物的可能。Objective： To evaluate the radiobiodistribution and internal dosimetry of ^188Re-DTPA-DG （diethylenetriaminepentaacetic acid- deoxyglucose） in target organs in nude mice bearing MCF-7 mammary cancer cell. Methods 3, 12 and 24h after the ^188Re-DTPA-DG injection, the mice were killed and biodistribution in mice was determined.Radiation dosimetry in humans was calculated according to the organ distribution in mice and the standard MIRD method. Results： The equivalent dose per injected received by the tumor was 255.32mSv/ MBq. Doses received by other organs between 0.002 and 6.850 mGy/MBq.The effective dose was estimated to be 1.420 mSv/MBq. Conclusion：The dosimetry of the ^188Re-DTPA-DG complex indicated that this pharmaceutical could be used in radiotherapy and radionuclide imaging of tumor.

关 键 词：^188Re—DTPA—DG MCF-7乳腺癌 体内分布 吸收剂量 

分 类 号：R817[医药卫生—影像医学与核医学]