经冠状静脉置管测定快速心房起搏后左右心房有效不应期的变化  

Effect of short-term rapid atrial pacing on atrial effective refractory period determined by coronary sinus catheter.

作　　者：侯月梅[1] 张小琴[1] 杨斌[1] 孙娟[1] 宋建国[1] 马小洁[1] 范平[1] 刘瑜伟[1] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐830054

出　　处：《中国心脏起搏与心电生理杂志》2008年第5期420-422,共3页Chinese Journal of Cardiac Pacing and Electrophysiology

基　　金：国家自然基金资助项目(项目编号:30560050)

摘　　要：目的探讨经冠状静脉置管测定快速右房起搏过程不同时间段左、右心房的有效不应期(ERP)变化。方法健康杂种犬9只经心脏超声引导,放置冠状静脉导管、高位右房导管;高位右房600次/分连续起搏24 h,于1,4,12,24 h分别行左、右心房ERP测定及超声心动图检查。结果左、右心房的ERP自4 h逐渐缩短;左、右心房的ERP变化于刺激前均呈频率依赖性,于开始刺激4 h后频率依赖性消失,12 h后左房频率依赖性消失;且左房ERP的变化大于右房。结论24 h快速心房起搏所致左、右房电重构的变化不一致。Objective To investigate whether acute eleetrophysiological remodeling caused by short-term rapid pacing of right atrium. Methods The catheter was conducted by echoeardiography and eleetrophysiology. The atrial pacing was performed with a rate of 100 ms for 24 hours to establish atrial fibrillation canine models and effective refractory period （ERP） of high right atrium（HRA） and coronary vein octium distant （CSOd） were determined by program stimulation during 0,4,12, 24 h. Results The experiment was conducted in 9 dogs. The ERP of left and right atrium was shortened gradually after 4 hours, and the adjusted ERP of both atriums disappeared after 12 hours . There was difference between right and left atriums in the change of ERP. Conclusions There is a different electrophysiologieal remodeling between right and left atriums after rapid atrial pacing. [ Chinese Journal of Cardiac Pacing and Electrophysiology, 2008,22 （5） ：420 -422 ]

关 键 词：电生理学 心房颤动 有效不应期 超声心动描记术 

分 类 号：R331.38[医药卫生—人体生理学] R318.11[医药卫生—基础医学]