30种抗菌药物对临床分离葡萄球菌体外抗菌作用的研究  

In vitro activity of 30 antibacterial agents against staphylococci isolated clinically

作　　者：李胜利[1] 张婴元[1] 周乐[1] 汪复[1] 

机构地区：[1]上海医科大学华山医院

出　　处：《中国抗生素杂志》1997年第6期447-450,S1,共5页Chinese Journal of Antibiotics

基　　金：国家博士点基金

摘　　要：为比较抗菌药物对临床分离葡萄球菌的作用，我们采用琼脂双倍稀释法测定了３０种抗菌药物对２４０株金葡萄球菌和２１１株凝固酶阴性葡萄球菌的最低抑菌浓度。结果万古霉素和去甲万古霉素对所有菌株的抑菌率达１００％。多数药物对甲氧西林敏感葡萄球菌作用良好，苯唑西林、头孢替安、头孢唑林、利福平、亚胺培南和异帕米星的抑菌率均在９５％～１００％。多数药物对甲氧西林耐药葡萄球菌作用差，但替考拉宁、利福平和异帕米星对ＭＲＳＡ的抑菌率较高，分别为９８．５％，９４．３％和９２．３％。对耐甲氧西林凝固酶阴性葡萄球菌抑菌率较高的有奈替米星（８６．６％），异帕米星（８５．７％），利福平（８１．３％）和阿米卡星（６９．６％）。This experiment was undertaken to compare the activity of 30 antibacterial agents against staphylococci isolated clinically. Two hundred forty strains of S.aureus and 211 strains of coagulasenegative staphylococcus were collected and identified. Minimal inhibitory concentrations of the antibacterial agents against the ioslates were determined by agar dilution method. The results showed that vancomycin and norvancomycin could inhibit all isolates tested. Most of the durgs were active against methicillinsensitive staphylococcus. The inhibition rates of oxacillin, cefotiam, cefazolin, rifampin, imipenem and isepamicin were from 95% to 100%. Most of the inhibition rates of the tested agents for methicillinresistant staphylococcus were lower than 50%. But teicoplanin, rifampin and isepamicin were active against MRSA isolates with inhibition rates of 98.5%, 94.3% and 92.3% respectively. The inhibition rates of netilmicin (86.6%), isepamicin (85.7%), rifampin (81.3%) and amikacin (69.6%) for methicillinresistant coagulasenegative staphylococcus isolates were relatively higher. 

关 键 词：MRSA 葡萄球菌 最低抑菌浓度 抗菌素 CNS 

分 类 号：R978.1[医药卫生—药品] R378.11[医药卫生—药学]