黄芪皂苷甲对离体兔主动脉环和离体豚鼠右心房的作用  

Effects of Astramembrannin I (ASI) on Isolated Aortic Rings of Rabbit And Isolated Right Atria of Guinea Pig

作　　者：李明亚[1,2] 张银娣[1,2] 陈曦[1,2] 郭力[1,2] 沈建平 

机构地区：[1]广东药学院药理教研室 [2]南京医科大学药理教研室

出　　处：《广东药学院学报》1997年第4期219-221,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：用离体器官实验法，在离体兔主动脉环和离体豚鼠右心房上研究黄芪甲苷（ＡＳＩ）对心血管的作用，并与维拉帕米（Ｖｅｒ）的作用相比较。结果：ＡＳＩ对ＫＣｌ和ＣａＣｌ２所致兔主动脉环收缩，呈非竞争性拮抗，ＰＤ２值分别为３．１１和３．５７，ＡＳＩ的作用弱于Ｖｅｒ。ＡＳＩ对豚鼠离体右心房自发性节律有抑制作用，此作用能被Ｃａ２＋对抗。表明ＡＳＩ对ＫＣｌ和ＣａＣｌ２所致的离体兔主动脉环收缩和对离体豚鼠右心房自发性节律有抑制作用，此作用似乎与拮抗Ｃａ２＋有关。The isolated aortic rings of rabbit and isolated right atria of guinea pig were used for the investigating of the effects of ASI on cardiovascular system. The effects of ASI were compared with those of verapamil(Ver).The results showed that ASI shifted the dose response curve of CaCl 2 and KCl to the right in a nonparallel fashion and decresed their maximal response, showing noncompetitive antagonism.The values of pD 2 were 3.11 and 3.57 respectively.The action of ASI was less in potency than that of Ver.The result also showed that ASI inhibited the normal automaticity of the isolated right atria of guinea pig. This effect can be antagonized by 5 mmol/L CaCl 2. The above information suggests that ASI could inhibite the normal automaticity of the isolated right atria of guinea pig and the CaCl 2 or KCl-induced contraction in the isolated aortic rings of rabbit. The inhibitory effect of ASI seems to be associated with the antagonization of calcium ion.

关 键 词：黄芪皂苷甲 胸主动脉环 离体右心房 ASI 

分 类 号：R285.5[医药卫生—中药学]