乳腺增生病辨证分型与性激素、钼靶X线指标的相关性  

Relation among TCM Syndromes,Sex Hormones and Molybdenum Target Radiography Image of Mammary Hyperplasia

作　　者：楼丽华[1] 边林莉[1] 沃兴德[2] 

机构地区：[1]浙江中医药大学附属第一医院乳腺病中心,浙江省杭州市邮电路54号310006 [2]浙江中医药大学生命科学学院

出　　处：《中医杂志》2008年第9期800-802,共3页Journal of Traditional Chinese Medicine

基　　金：浙江省自然科学基金资助项目(Y204329)

摘　　要：目的探讨乳腺增生病中医辨证分型与性激素、钼靶X线的关系,建立乳腺增生病中医辨证分型的客观指标。方法346例乳腺增生病患者经中医辨证分为肝郁气滞、痰瘀互结、冲任失调3型,测定其排卵期垂体性腺激素,包括雌二醇(E2)、孕酮(PP)、睾酮(PT)、催乳素(PRL)、卵泡刺激素(FSH)及黄体生成素(LH)值,同时进行钼靶X线检查。结果乳腺增生病患者排卵期FSH、LH、E2值均明显降低(P<0.05),PRL、PP值明显增高(P<0.05),PT值无显著变化。冲任失调型FSH值高于肝郁气滞型(P<0.05),肝郁气滞型LH值高于冲任失调型(P<0.05);E2按肝郁气滞型、痰瘀互结型、冲任失调型依次减低。乳腺钼靶X线图像表现为肝郁气滞型和痰瘀互结型以小叶型为主,结节型次之;冲任失调型以结节型为主,小叶型次之。结论乳腺增生病患者排卵期垂体—性腺激素水平呈紊乱状态,不同中医辨证分型患者的性激素、钼靶X线影像学改变特征各不相同,性激素、钼靶X线影像学改变可作为中医辨证分型的客观指标之一。Objective To explore the correlation between the TCM syndromes of mammary hyperplasia patients and their sex hormones, molybdenum target radiography image to establish the objective indexes for its syndrome differentiation. Methods According to the TCM syndrome differentiation, the 346 patients with mammary hyperplasia were diagnosed liver qi stagnation syndrome, phlegm and blood-stasis syndrome, and chong and ren dysfunction syndrome. Their pituitary gonad stimulating hormones, including estradiol （E2）, progesterone （PP）, testosterone （PT）, prolactin releasing hormone （PRL）, follicle-stimulating hormone （FSH）, and luteotropie hormone （LH） were measured during ovulatory period. At the same time, the molybdenum target radiography examination was given. Results The level of FSH, LH and E2 in mammary hyperplasia patients during ovulatory period was obviously lower, the level of PRL and PP was obviously higher, and the level of PT was not obviously changed. The comparison among groups showed that the level of FSH in thong and ren dysfunction patients was higher than that in liver qi stagnation patients, but the level of LH of the two was just opposite; the level of E2 was lower in an order of liver qi stagnation, phlegm and blood-stasis, and ehong and ten dysfunction patients; the molybdenum target radiography image showed that there was mainly the lobular hyperplasia in liver qi stagnation and phlegm and blood-stasis patients and then the nodular type ; but there was mainly nodular hyperplasia in chong and ren dysfunction patients and then the lobular type. Conclusion The pituitary gonad stimulating hormones of mammary hyperplasia patients were disordered in the duration of ovulatory period. The level of sex hormones and change of molybdenum target radiography image were different in different TCM syndromes and they can be used as one of the objective indices in TCM syndrome differentiation for diagnosis.

关 键 词：乳腺增生病 辨证分型 垂体-性腺激素 钼靶X线 

分 类 号：R271.44[医药卫生—中医妇科学]