姜黄素对大鼠肝缺血再灌注早期肝组织中氧自由基生成的影响  

Effects of curcumin on contents of oxygen free radicals in the liver early ischemia/reperfusion rats

作　　者：向进见[1] 田夫[1] 沈世强[2] 童仕伦[2] 李明忠[1] 程本静[1] 

机构地区：[1]湖北省荆州市长江大学附属第一医院普通外科,434000 [2]武汉大学人民医院普外科

出　　处：《腹部外科》2008年第5期315-316,共2页Journal of Abdominal Surgery

摘　　要：目的探讨姜黄素对大鼠肝脏缺血再灌注早期损伤的氧自由基生成的影响。方法将大鼠随机分为假手术组、对照组(肝血流阻断前30min和再灌注开始时经肠系膜上静脉各注入二甲基亚砜1ml)和实验组(姜黄素40mg/kg溶于二甲基亚砜1ml注入,余同对照组)。通过检测再灌注早期1、3h血清转氨酶水平、组织病理学改变及肝组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)的含量来评价姜黄素对大鼠肝脏缺血再灌注早期损伤氧自由基生成的影响。结果姜黄素可降低大鼠肝脏缺血再灌注早期1、3h血清转氨酶水平,可增加肝组织中SOD、CAT含量,降低肝组织中MDA含量。结论姜黄素可通过减少肝组织氧自由基生成,减少肝缺血再灌注肝实质细胞的受损。Objective To explored effects of oxygen free radicals formation of curcumin in the early hepatic ischemia/reperfusion（reperfusion for 1h）rats. Methods Wistar rats were randomized into the following groups：Sham operation group,control group（DMSO 1 ml for two times）and experiment group（40 mg/kg curcumin for two times）. Level of transaminase in serum, the change of histopatholo- gy and level of superoxide dismutase （SOD）, malondialdehyde（MDA）and catalase（CAT）in liver tissues were determined to evaluate the effect of curcumin on contents of oxygen free radicals in the early injury of ischemia/reperfusion（reperfusion for lh and 3 h）. Results Curcumin declined the level of transaminase in serum and MDA in liver tissue, at the same time,increased SOD,CAT in liver tissue. Conclusion Curcumin can relieve the injury of hepatic ceil by decreasing the level of oxygen free radicals formation in the early ischemia/reperfusion.

关 键 词：姜黄素 活性氧 肝 再灌注损伤 

分 类 号：R285.5[医药卫生—中药学] R657.3[医药卫生—中医学]