紫草总酚酸辅助米非司酮对妊娠大鼠的抗早孕作用  

Phenolic acids from Arnebia euchroma mifepristone in anti-earlypregnancy of SD rattus norvegicus

作　　者：王丽君[1,2] 张鑫毅[2] 廖矛川[1,2] 

机构地区：[1]中南民族大学,湖北武汉430074 [2]上海市计划生育科学研究所,上海200032

出　　处：《中国中药杂志》2008年第20期2378-2381,共4页China Journal of Chinese Materia Medica

基　　金：国家863项目(2003AA2Z3519)

摘　　要：目的：观察紫草总酚酸辅助米非司酮对妊娠大鼠的抗早孕作用。方法：对SD大鼠于妊娠第7～9天给药，观察妊娠抑制率；用放射免疫法测定血清中孕酮和雌二醇的水平。结果：大鼠口服紫草总酚酸720mg·kg^-1能够显著性提高米非司酮（8.0mg·kg^-1）的妊娠抑制率（P〈0.05），并增加实验组平均死胎数。对血清孕酮水平没有明显影响，也不能增加米非司酮引起的血清雌二醇水平的升高。结论：紫草总酚酸辅助米非司酮对妊娠SD大鼠的抗早孕作用明显，其抗早孕作用不是通过降低孕酮水平或升高雌二醇水平来实现的。Objective： Observing the effect of phenolic acids from Arnebia euchroma assist mifepristone in anti-earlypregnancy of SD rattus norvegicus. Method： Feed the SD rattus norvegicus with phenolic acids from A. euchroma during the 7 th to 9 th day, and then we observe the restaining rate of pregnancy. At the same time, we determine the progesterone level in blood serum in the ways of radioimmunoassay. Result： 720g·kg^-1 enolic aids from A. euchroma can markedly increase the restaining rate of pregnancy （P 〈 0.05 ） than that only mifepristone dose （8. 0g·kg^-1）. In addition, the number of everage still bith increase, however, to the pogestcrone level in blood serum. It has little effect. Conclusion. The effect of phenolic acids from A. euchroma assist mifepristone in antiearlypregnancy of SD rttus norvegicus is clear, and it dosen＇t work in the ways of decreasing the pogesterone level.

关 键 词：紫草总酚酸 妊娠大鼠 抗早孕 

分 类 号：R285.5[医药卫生—中药学]