大黄中蒽醌衍生物的构效关系  

Review about structure-function relationships of anthraquinone derivatives from Radix et Rhizoma Rhei

作　　者：宗金锐[1] 巢志茂[2] 刘振丽[3] 王金[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]中国中医科学院医学实验中心,北京100700 [3]中国中医科学院中医基础理论研究所,北京100700

出　　处：《中国中药杂志》2008年第20期2424-2427,共4页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局留学回国人员科技项目(国中医药研2006LHR06号)

摘　　要：从构效关系角度对大黄中存在的天然蒽醌衍生物进行综述。该类蒽醌衍生物具有相同的母核,因此体现出一些相同的药理活性,但因取代基的不同而表现出活性强度的不同。这些蒽醌衍生物在抗氧化,抗菌,抗癌,对免疫功能的影响等方面存在明显的构效关系,表现为活性的强度与取代基的氧化程度。It review the structure-function relationship of natural anthraquinone derivatives from Radix et Rhizoma Rhei. The anthraquinone derivatives had many identical activities because they have the identical mother nucleus ; but the strength of their activities were different, because they have different substitution groups. The anthraquinone derivatives shown the obvious structure-function relationship in many respects, such as antioxygenation, antibiosis, anticancer, the influence of immunity and so on.

关 键 词：大黄 蒽醌衍生物 构效关系 

分 类 号：R284.1[医药卫生—中药学]