蛋白质糖基化病理生理的研究进展  

Pathophysiological significance and development of advanced glycosylation end - products (AGEs).

作　　者：金晖[1] 刘乃丰[1] 唐尧[1] 

机构地区：[1]南京铁道医学院心血管内科,南京210009

出　　处：《中国病理生理杂志》1997年第6期758-761,共4页Chinese Journal of Pathophysiology

摘　　要：There are increasing evidences that the primary caustal factor for the development of most dibetic complications is prolonged exposure to hyperglycemia. One of the major pathophysiological con sequences of hyperglycemia is that the chemical interaction of glucose with proteins forms advanced glycosyla glycosylation end- products (AGEs), which may account for numemes features of diabetic complications and aging.In the review,the structural aspets, direct and indirect pathogenic significance of AGEs,clinical considera tions,the relationship of AGEs with aging (espeially Alzheimer’s disease), inhibition of AGEs formation and its achvity were discussed.There are increasing evidences that the primary caustal factor for the development of most dibetic complications is prolonged exposure to hyperglycemia. One of the major pathophysiological con sequences of hyperglycemia is that the chemical interaction of glucose with proteins forms advanced glycosyla glycosylation end- products (AGEs), which may account for numemes features of diabetic complications and aging.In the review,the structural aspets, direct and indirect pathogenic significance of AGEs,clinical considera tions,the relationship of AGEs with aging (espeially Alzheimer's disease), inhibition of AGEs formation and its achvity were discussed.

关 键 词：糖尿病 蛋白质 糖基地 病理学 生理学 

分 类 号：R587.102[医药卫生—内分泌]