辛伐他汀对血液透析患者血清Prohepcidin水平的影响  

The leverage of simvastatin on serum prohepcidin in patients with maintenance hemodialysis:A preliminary clinical study

作　　者：李向阳 李就鸿 常巨平 张军 彭伯深 祝胜郎 陈结慧 蒋莹 

机构地区：[1]广东省深圳市第六人民医院肾内科,深圳518000

出　　处：《中国血液净化》2008年第10期534-537,541,共5页Chinese Journal of Blood Purification

基　　金：广东省深圳市南山区科技局科研基金(2006029)

摘　　要：目的前瞻性观察辛伐他汀对维持性血液透析患者血清Prohepcidin浓度的影响。方法将26例维持性血液透析(MHD)患者分为实验组(13例)和对照组(13例),测定基线血清Prohepcidin,血浆IL-6,以及血清C反应蛋白(CRP)、铁蛋白、血红蛋白、白蛋白、胆固醇、三酰甘油、低密度脂蛋白和高密度脂蛋白浓度。实验组每晚口服辛伐他汀20mg共8周,对照组不使用辛伐他汀类或其它调脂药物。观察两组实验前后上述指标变化。结果26例MHD患者实验前血清Prohepcidin浓度为(173.6±52.7)ng/mL。实验组实验前血清Prohepcidin浓度为(156.7±51.9)ng/ml,8周后为(180.5±33.7)ng/mL,与基线相比无显著性差异,P=0.127。对照组实验前血清Prohepcidin浓度为(190.6±49.6)ng/ml,8周后为(193.5±36.0)ng/ml,与基线相比无显著性差异,P=0.728。实验组8周后血清胆固醇和三酰甘油浓度分别降低18.6%(P=0.004)和55.1%(P=0.007);实验及对照组实验前后血浆IL-6,血清CRP、铁蛋白、血红蛋白、白蛋白、低密度脂蛋白和高密度脂蛋白浓度无显著变化。结论本实验初步显示,每晚口服辛伐他汀20mg8周未能对MHD患者血清Prohepcidin浓度产生显著影响。Objective To prospectively study the leverage of simvastatin on serum prohepcidin in mainte-nance hemodialysis（MHD） patients.Methods We assigned 26 MHD patients equally into experiment group and control group.Patients in the experiment group took 20mg simvastatin orally per night for 8 weeks,and those in the control group treated without statins and any other lipid modulating drugs.Before and after experiment,serum prohepcidin,plasma IL-6,and serum C-reactive protein（CRP）,ferritin,hemoglobin,albumin,cholesterol,triglycerides,low-density lipoprotein（LDL） and high-density lipoprotein（HDL） were determined.Results Of the 26 MHD pa-tients before the experiment,serum prohepcidin was（173.6±52.7）ng/ml.In the experiment group,serum prohepcidin was（156.7±51.9）ng/ml before the treatment,and was（180.5±33.7）ng/ml after the treatment for 8 weeks（P=0.127）.In the control group,serum prohepcidin was（190.6±49.6）ng/mL at the beginning,and was（193.5±36.0）ng/ml after 8 weeks（P =0.728）.In the experiment group after simvastatin treatment for 8 weeks,serum cholesterol and triglycer-ides decreased by 18.6%（P =0.004） and 55.1%（P = 0.007）,respectively.In the 2 groups,plasma IL-6 and serum CRP,ferritin,hemoglobin,albumin,LDL and HDL remained unchanged.Conclusion Our preliminary study demon-strated that simvastatin 20mg per day did not change serum prohepcidin significantly in MHD patients.

关 键 词：PROHEPCIDIN HEPCIDIN 辛伐他汀 血液透析 CRP IL-6 

分 类 号：R459.5[医药卫生—治疗学] R318.16[医药卫生—临床医学]