肾综合征出血热患者T细胞亚群数量与白细胞介素2、4水平变化的关系  

Relationship Between Numeric Changes of T Lymphocyte Subpopulations and Serial Levels of Interleukin-2 and 4 in Hemorrhagic Fever with Renal Syndrome

作　　者：唐永明[1] 张长法[1] 王晶[1] 胡峻[1] 张斌[2] 

机构地区：[1]解放军第四五四医院,210002 [2]第四军医大学唐都医院

出　　处：《江苏医药》1997年第12期833-835,共3页Jiangsu Medical Journal

摘　　要：采用ABC免疫组化染色法及单克隆抗体夹心法ELISA，同步检测了34例肾综合征出血热（HFRS）患者外周血T细胞亚群数量和血清白细胞介素2和4（IL－2、IL－4）水平。发现HFRS病程中各T细胞亚群数量均有不同程度的升高，其中CDS阳性T细胞在各病期均有升高。IL－4水平升高仅见于发热期．而IL－2的升高主要在低血压期和少尿期。病程中有CD4／CD8比值的下降甚至倒置。这种比值的变化与IL－2和IL－4的动态变化有一定的相关性。结果揭示，在HFRS发病机理中存在Thl型和Th2型免疫反应等多种免疫病理机制。ABC immunocytochemistry and monoc1onal antibody sandwich EL1SA were applied simultaneous1y to study 34 cases of epidemic hemorrhagic fever(EHF) for the changes of numbers of lymphocyte subsets in peripheraI b1ood and the levels of IL-2 and IL-4 in serum. The results showed that there was significant increase in the number of T lymphocyte subsets. A remarkable increase of CD, positive cells was seen in different stages of EHF. The increase of IL-4 level was only observed in the febrile stage,while the increase of IL-2 1evel mainly occurred in hypotensive and oliguria stages. Such changes of cytokines were significantly related with the changes of CD4/CD8 ratio. The results suggest that more than one kind of immune responses may exist in. such as Thl and Th2 reaction models in the immuno-pathogenesis of EHF.

关 键 词：肾综合征出血热 发病机理 细胞因子 T细胞亚群 

分 类 号：R512.803[医药卫生—内科学]