丹皮酚对大鼠反复性脑缺血的保护作用  

Protective Effect of Paeonol on Repeated Cerebral Ischemia in Rats

作　　者：张广钦[1] 禹志领[1] 赵厚长 

机构地区：[1]中国药科大学,南京210009 [2]河南省商丘地区中药厂,商丘476000

出　　处：《中药材》1997年第12期626-628,共3页Journal of Chinese Medicinal Materials

摘　　要：采用大鼠反复性短暂脑缺血再灌注模型,观察丹皮酚的抗脑缺血作用。丹皮酚100,50mg/kg,ip 7d,均能不同程度降低脑缺血引起的脑组织Ca^(2+)聚集,改善Ca^(2+)-ATPase活性,抑制超氧化物歧化酶(SOD)活性下降及丙二醛(MDA)含量增加,显示了对脑缺血的保护作用。结果表明,丹皮酚改善脑缺血作用与其抑制细胞Ca^(2+)内流及抗氧自由基作用有关。Protcective effect of paeonol was observed in the repeated cerebral ischemia-reperfusion model in rats. Paeonol (100, 50 mg/kg X 7d ip) could inhibit the increase of Ca2+, the decrease of superoxide dimutase (SOD) activity and the content of malondialdehyde (MDA) , improve Ca2+-ATPase activity in ischemia brain tissue. The results showed that paeonol could protect cerebral ischemia by inhibiting accumulation of Ca2+ and production of oxygen free radical.

关 键 词：脑缺血 保护 丹皮酚 氧自由基 中药 

分 类 号：R286.2[医药卫生—中药学] R277.733[医药卫生—中医学]