吗啡条件性位置偏爱大鼠脑伏核中CaMK Ⅱ及NOS阳性神经元变化  

THE CHANGES OF CaMK Ⅱ AND NOS POSITIVE NEURONS IN NUCLEUS ACCUMBENS OF RATS WITH MORPHINE INDUCED CONDITIONED PLACE PREFERENCE

作　　者：李峰[1] 刘洋[1] 焦莹[1] 宋月晗[1] 赵雪松[1] 刘晓兰[1] 刘燕[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国药物依赖性杂志》2008年第5期341-343,共3页Chinese Journal of Drug Dependence

基　　金：教育部高等学校博士学科点专向科研基金资助(20070026001)

摘　　要：目的:研究吗啡条件性位置偏爱(CPP)大鼠伏核中CaMK Ⅱ及NOS的阳性神经元变化。方法:采用免疫组织化学实验方法观察CaMK Ⅱ及NOS阳性神经元的形态及数目的变化。结果:与正常对照组比较,吗啡模型组CaMK Ⅱ及NOS的阳性神经元数均明显升高(P<0.01)。结论:吗啡CPP大鼠伏核中显示CaMK Ⅱ及NOS的阳性神经元增多,参与了吗啡精神依赖的形成。Objective：To study changes of CaMK Ⅱ and NOS positive neurons in nucleus accumbens of rats with morphine-induced conditioned place preference（CPP）. Methods：Using immunohistochemistry method to observe CaMK Ⅱ and NOS positive neurons＇ morphology and numbers. Results：CaMK Ⅱ and NOS positive neurons increased significantly（P〈0.01）in morphine induced CPP rats compared with that in normal control group. Conclusion：The increased CaMK Ⅱ and NOS positive neurons in nucleus accumbens of morphine induced CPP rats involves in the formation of morphine psychological dependence.

关 键 词：精神依赖 吗啡 伏核 CAMK Ⅱ NOS 条件性位置偏爱 大鼠 

分 类 号：R338.1[医药卫生—人体生理学] R595.5[医药卫生—基础医学]