中国汉族人群载脂蛋白E基因多态性与2型糖尿病肾病相关性的Meta分析  

Meta-analysis of the association of ApoE gene polymorphisms with type 2 diabetic nephropathy in Chinese Han population

作　　者：李生兵[1] 杨刚毅[1] 李伶[2] 刘桦 

机构地区：[1]重庆医科大学附属第二医院内分泌科,400010 [2]重庆医科大学检验系临床生化教研室和教育部实验诊断重点实验室 [3]美国Mississippi大学医学中心

出　　处：《中国糖尿病杂志》2008年第10期580-583,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金项目(30370671);重庆市教委科研基金(KJ050304)

摘　　要：目的评价中国汉族人群载脂蛋白E（ApoE）基因多态性与2型糖尿病肾病（T2DN）的相关性。方法全面检索T2DN与ApoE基因多态性的相关文献,用Meta分析方法对研究结果进行数据合并,并评价分析结果稳定性和可靠性。结果T2DN组较之T2DNN组ApoE基因E2、E2/E2和E2/E3的合并OR值及其95%CI分别为2.08（1.55-2.77）、2.75（1.09-7.01）和2.10（1.48-2.96）（P〈0.05）,T2DN组较之NC组分别为2.62（2.01-3.41）、3.63（1.61-8.16）和2.64（1.67-4.16）（P〈0.05）。T2DN组较之T2DNN组E3和E3/E3的合并OR值及其95%CI分别为0.67（0.54-0.82）和0.62（0.48-0.79）（P〈0.05）,T2DN组较之NC组为0.53（0.41-0.70）和0.49（0.39-0.62）（P〈0.05）。结论中国汉族人群T2DN与ApoE基因多态性关系密切,等位基因E2是T2DN的危险因子,等位基因E3可能是T2DN的保护因子。Objective To evaluate the association of ApoE gene polymorphism with type 2 diabetic nephropathy（T2DN） in Chinese Han population. Methods Odds ratios （ORs） of ApoE allele/genotype distribution in T2DN, type 2 diabetic non-nepbropathy （T2DNN） and healthy controls （NC） were analyzed. Relative literatures were fully searched and screened through the computed database. The pooled OR and its 95% CI were calculated with these studies by the method of meta-analysis. The evaluation of the reliability and stability of the meta-analysis results were performed. Results The pooled ORs and 95 % CIs of allele E2, genotype E2/E2 and genotype E2/E3 of ApoE gene of T2DN vs. T2DNN and T2DN vs. NC were 2.08 [1.55, 2.77], 2.75 [1.09, 7.01], 2.10 [1.48, 2.96], 2.62 [2.01, 3.41], 3.63 [1.61, 8.16] and 2.64 [1.67, 4. 16], respectively （P〈0.05） in Chinese Han population. The pooled ORs and 95% CIs of allele E3 and genotype E3/E3 of ApoE gene in T2DN vs. T2DNN and T2DN vs. NC were 0. 67 [0. 54, 0. 82], 0. 62 [0.48, 0. 79], 0. 53 [0.41, 0. 70] and 0. 49 [0.39, 0.62], respectively （P〈 0.05） in Chinese Han population, conclusions ApoE gene polymorphism is associated with T2DN in Chinese Han population. E2 allele is a risk factor for T2DN, and E3 allele may be protective for T2DN.

关 键 词：糖尿病肾病 2型 载脂蛋白E 基因多态性 META分析 

分 类 号：R587.2[医药卫生—内分泌]