青岛市社区中老年人群高尿酸血症流行病学调查  

Epidemiological survey of hyperuricacidemia among adults aged 40-74 years in Qingdao city community

作　　者：董砚虎[1] 南海荣[1] 钱薇薇[1] 高维国[1] 石海燕[1] 李利平[1] 马臻[1] 付方明[1] 

机构地区：[1]青岛市内分泌糖尿病医院,266071

出　　处：《中国糖尿病杂志》2008年第10期601-603,635,共4页Chinese Journal of Diabetes

摘　　要：目的调查中老年人群高尿酸血症（HUA）的患病率以及影响因素。方法分层随机整群抽样,横断面调查青岛市湛山社区40-74岁居民1706名,问卷调查,体格检查,检测空腹血尿酸（SUA）、血脂、血糖等。结果（1）调整年龄后SUA水平均值为342.6μmol/L（男388.0μmol/L,女317.6μmol/L）,同年龄组男性SUA显著高于女性,仅女性SUA水平随年龄增长呈总体上升趋势（P〈0.01）。（2）HUA的粗患病率为25.1%。按2000年全国人口普查年龄构成计算,男女HUA标化患病率分别为29.5%和20.5%%,标化患病率分别为23.3%。（3）多因素线性回归结果表明,BMI、TG、BP、饮酒、增龄与SUA相关性最高。结论青岛市社区居民HUA患病率较高,肥胖、脂代谢异常、高血压、饮酒、高嘌呤饮食和增龄是影响SUA的重要相关因素。Objective To estimate the prevalence of hyperuricemia （HUA） and risk factors for HUA in a Chinese population of Qingdao city community. Methods A cross-sectional population survey for hyperuricemia was performed in 2002. Questionnaire were conducted in 1706 subjects, and levels of serum UA, lipid-profile, as well as height, weight, blood pressure were measured. Hyperuricemia was defined as serum UA levels 〉420 μmol/l in men and 〉360 μmol/l in women. All statistical analyses were performed using SPSS. Results Age-adjusted mean serum UA level was 388. 0μmol/l in men and 317. 6μmol/l in women. Serum UA was increased with age in women only （P for trend 〈0. 001）. The age-standardized prevalence was 23.3% for hyPerurieemla in adults aged 40 to 74 years. Hyperuricemia was more in men than in women （29.5% vs 20. 5%, P〈0. 001）. In multivariate regression analysis, serum UA was significantly and independently associated with BMI, triglyceride and alcohol drinking in men, and these variables explained 15.0% of the variation in serum UA. In women. UA was correlated directly with BMI, triglyceride, total cholesterol and systolic blood pressure, which accounted for 13.0% of serum UA variations. Conclusions The prevalence of hyperuricemia in the urban adult population in Qingdao city is high. Obesity, hypertension, and dyslipidemia are the major factors associated with serum UA. Interventions by limiting the purine-rich foods to prevent a further increase in hyperuricemia may simultaneously reduce the risk for cardiovascular disease.

关 键 词：血尿酸 高尿酸血症 患病率 

分 类 号：R589[医药卫生—内分泌]